Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun; Young Mook Lee; Chiho Kim; Hirohiko Shibayama; Akira Tanimura; Yuri Hamanaka; Yuzuru Kanakura; Il Seon Park; Areum Jo; Joo Ho Shin; Chung Ju; Won Ki Kim; Young J. Oh

doi:10.1074/jbc.M114.552679

Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun, Young Mook Lee, Chiho Kim, Hirohiko Shibayama, Akira Tanimura, Yuri Hamanaka, Yuzuru Kanakura, Il Seon Park, Areum Jo, Joo Ho Shin, Chung Ju, Won Ki Kim, Young J. Oh

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

Original language	English (US)
Pages (from-to)	22183-22195
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.552679
State	Published - Aug 8 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Anamorsin, a novel caspase-3 substrate in neurodegeneration",

abstract = "Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.",

author = "Nuri Yun and Lee, {Young Mook} and Chiho Kim and Hirohiko Shibayama and Akira Tanimura and Yuri Hamanaka and Yuzuru Kanakura and Park, {Il Seon} and Areum Jo and Shin, {Joo Ho} and Chung Ju and Kim, {Won Ki} and Oh, {Young J.}",

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doi = "10.1074/jbc.M114.552679",

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T1 - Anamorsin, a novel caspase-3 substrate in neurodegeneration

AU - Yun, Nuri

AU - Lee, Young Mook

AU - Kim, Chiho

AU - Shibayama, Hirohiko

AU - Tanimura, Akira

AU - Hamanaka, Yuri

AU - Kanakura, Yuzuru

AU - Park, Il Seon

AU - Jo, Areum

AU - Shin, Joo Ho

AU - Ju, Chung

AU - Kim, Won Ki

AU - Oh, Young J.

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

AB - Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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Anamorsin, a novel caspase-3 substrate in neurodegeneration

Abstract

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