Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy

Aarti Bhatia; Archana Rao; Kie Kian Ang; Adam S. Garden; William H. Morrison; David I. Rosenthal; Douglas B. Evans; Gary Clayman; Steven I. Sherman; David L. Schwartz

doi:10.1002/hed.21257

Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy

Aarti Bhatia, Archana Rao, Kie Kian Ang, Adam S. Garden, William H. Morrison, David I. Rosenthal, Douglas B. Evans, Gary Clayman, Steven I. Sherman, David L. Schwartz

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Background. The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT). Methods. In all, 53 consecutive patients were analyzed. Thirty-one (58%) patients were irradiated with curative intent. Median radiation dose was 55 Gray (Gy; range, 4-70 Gy). Thirteen (25%) patients received IMRT to a median 60 Gy (range, 39.9-69.0 Gy). Thirty-nine (74%) patients received chemotherapy with radiation. Results. The Kaplan-Meier estimate of overall survival (OS) at 1 year for definitively irradiated patients was 29%. Patients without distant metastases receiving ≥50 Gy had superior survival outcomes; 5 such patients had no evidence of disease at last followup. Use of IMRT versus 3DRT did not influence toxicity. Conclusions. Outcomes for anaplastic thyroid cancer treated with 3DRT or IMRT remain equivalent to historical results. Healthy patients with localized disease who tolerate full dose irradiation can potentially enjoy prolonged survival. Biologically targeted radiosensitization merits prioritized investigation.

Original language	English (US)
Pages (from-to)	829-836
Number of pages	8
Journal	Head and Neck
Volume	32
Issue number	7
DOIs	https://doi.org/10.1002/hed.21257
State	Published - Jul 2010

Keywords

Anaplastic
Conformal
IMRT
Radiotherapy
Thyroid cancer

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.21257

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@article{f915f9824bde44538c646980f78477cf,

title = "Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy",

abstract = "Background. The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT). Methods. In all, 53 consecutive patients were analyzed. Thirty-one (58%) patients were irradiated with curative intent. Median radiation dose was 55 Gray (Gy; range, 4-70 Gy). Thirteen (25%) patients received IMRT to a median 60 Gy (range, 39.9-69.0 Gy). Thirty-nine (74%) patients received chemotherapy with radiation. Results. The Kaplan-Meier estimate of overall survival (OS) at 1 year for definitively irradiated patients was 29%. Patients without distant metastases receiving ≥50 Gy had superior survival outcomes; 5 such patients had no evidence of disease at last followup. Use of IMRT versus 3DRT did not influence toxicity. Conclusions. Outcomes for anaplastic thyroid cancer treated with 3DRT or IMRT remain equivalent to historical results. Healthy patients with localized disease who tolerate full dose irradiation can potentially enjoy prolonged survival. Biologically targeted radiosensitization merits prioritized investigation.",

keywords = "Anaplastic, Conformal, IMRT, Radiotherapy, Thyroid cancer",

author = "Aarti Bhatia and Archana Rao and Ang, {Kie Kian} and Garden, {Adam S.} and Morrison, {William H.} and Rosenthal, {David I.} and Evans, {Douglas B.} and Gary Clayman and Sherman, {Steven I.} and Schwartz, {David L.}",

year = "2010",

month = jul,

doi = "10.1002/hed.21257",

language = "English (US)",

volume = "32",

pages = "829--836",

journal = "Head and Neck",

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TY - JOUR

T1 - Anaplastic thyroid cancer

T2 - Clinical outcomes with conformal radiotherapy

AU - Bhatia, Aarti

AU - Rao, Archana

AU - Ang, Kie Kian

AU - Garden, Adam S.

AU - Morrison, William H.

AU - Rosenthal, David I.

AU - Evans, Douglas B.

AU - Clayman, Gary

AU - Sherman, Steven I.

AU - Schwartz, David L.

PY - 2010/7

Y1 - 2010/7

N2 - Background. The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT). Methods. In all, 53 consecutive patients were analyzed. Thirty-one (58%) patients were irradiated with curative intent. Median radiation dose was 55 Gray (Gy; range, 4-70 Gy). Thirteen (25%) patients received IMRT to a median 60 Gy (range, 39.9-69.0 Gy). Thirty-nine (74%) patients received chemotherapy with radiation. Results. The Kaplan-Meier estimate of overall survival (OS) at 1 year for definitively irradiated patients was 29%. Patients without distant metastases receiving ≥50 Gy had superior survival outcomes; 5 such patients had no evidence of disease at last followup. Use of IMRT versus 3DRT did not influence toxicity. Conclusions. Outcomes for anaplastic thyroid cancer treated with 3DRT or IMRT remain equivalent to historical results. Healthy patients with localized disease who tolerate full dose irradiation can potentially enjoy prolonged survival. Biologically targeted radiosensitization merits prioritized investigation.

AB - Background. The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT). Methods. In all, 53 consecutive patients were analyzed. Thirty-one (58%) patients were irradiated with curative intent. Median radiation dose was 55 Gray (Gy; range, 4-70 Gy). Thirteen (25%) patients received IMRT to a median 60 Gy (range, 39.9-69.0 Gy). Thirty-nine (74%) patients received chemotherapy with radiation. Results. The Kaplan-Meier estimate of overall survival (OS) at 1 year for definitively irradiated patients was 29%. Patients without distant metastases receiving ≥50 Gy had superior survival outcomes; 5 such patients had no evidence of disease at last followup. Use of IMRT versus 3DRT did not influence toxicity. Conclusions. Outcomes for anaplastic thyroid cancer treated with 3DRT or IMRT remain equivalent to historical results. Healthy patients with localized disease who tolerate full dose irradiation can potentially enjoy prolonged survival. Biologically targeted radiosensitization merits prioritized investigation.

KW - Anaplastic

KW - Conformal

KW - IMRT

KW - Radiotherapy

KW - Thyroid cancer

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Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy

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