Anatomic and pharmacologic differences between two types of aversive midbrain stimulation

R. Sanford Kiser, Robert M. Lebovitz, Dwight C. German

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Chronic stimulating electrodes were implanted into two separate midbrain sites in rats. One site was the dorsal central gray area (DCG), where electrical stimulation produced frantic, escape-seeking behavior which grossly appeared fear-like and/or pain-like. The other site was in the ventral reticular formation (VRF), where stimulation produced a stereotyped circling response. Stimulation at both sites was aversive in that these animals would bar press for escape in a decremental bar-pressing paradigm. In this paradigm, each bar press decremented the current by five per cent of the initial current level. Following the acquisition of stable baseline decremental bar-pressing performance, animals were given injections of either the serotonin-depleting drug, para-chlorophenylalanine (PCPA), or the catecholamine-depleting drug, alpha-methyl-para-tyrosine (AMPT). Control animals received normal saline. Compared to saline control animals, PCPA-injected DCG-stimulated animals showed a marked change. AMPT-injected VRF-stimulated animals showed a marked decrease in decremental bar pressing, but the DCG-stimulated animals were not affected. These results suggest that escape behavior from electrical stimulation of midbrain sites is mediated by more than one neural system.

Original languageEnglish (US)
Pages (from-to)331-342
Number of pages12
JournalBrain Research
Volume155
Issue number2
DOIs
StatePublished - Oct 27 1978

Fingerprint

Mesencephalon
Fenclonine
alpha-Methyltyrosine
Reticular Formation
Electric Stimulation
Serotonin Agents
Implanted Electrodes
Fear
Catecholamines
Pain
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Anatomic and pharmacologic differences between two types of aversive midbrain stimulation. / Sanford Kiser, R.; Lebovitz, Robert M.; German, Dwight C.

In: Brain Research, Vol. 155, No. 2, 27.10.1978, p. 331-342.

Research output: Contribution to journalArticle

Sanford Kiser, R. ; Lebovitz, Robert M. ; German, Dwight C. / Anatomic and pharmacologic differences between two types of aversive midbrain stimulation. In: Brain Research. 1978 ; Vol. 155, No. 2. pp. 331-342.
@article{137d6e0449004da491e743de11c05cba,
title = "Anatomic and pharmacologic differences between two types of aversive midbrain stimulation",
abstract = "Chronic stimulating electrodes were implanted into two separate midbrain sites in rats. One site was the dorsal central gray area (DCG), where electrical stimulation produced frantic, escape-seeking behavior which grossly appeared fear-like and/or pain-like. The other site was in the ventral reticular formation (VRF), where stimulation produced a stereotyped circling response. Stimulation at both sites was aversive in that these animals would bar press for escape in a decremental bar-pressing paradigm. In this paradigm, each bar press decremented the current by five per cent of the initial current level. Following the acquisition of stable baseline decremental bar-pressing performance, animals were given injections of either the serotonin-depleting drug, para-chlorophenylalanine (PCPA), or the catecholamine-depleting drug, alpha-methyl-para-tyrosine (AMPT). Control animals received normal saline. Compared to saline control animals, PCPA-injected DCG-stimulated animals showed a marked change. AMPT-injected VRF-stimulated animals showed a marked decrease in decremental bar pressing, but the DCG-stimulated animals were not affected. These results suggest that escape behavior from electrical stimulation of midbrain sites is mediated by more than one neural system.",
author = "{Sanford Kiser}, R. and Lebovitz, {Robert M.} and German, {Dwight C.}",
year = "1978",
month = "10",
day = "27",
doi = "10.1016/0006-8993(78)91026-0",
language = "English (US)",
volume = "155",
pages = "331--342",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Anatomic and pharmacologic differences between two types of aversive midbrain stimulation

AU - Sanford Kiser, R.

AU - Lebovitz, Robert M.

AU - German, Dwight C.

PY - 1978/10/27

Y1 - 1978/10/27

N2 - Chronic stimulating electrodes were implanted into two separate midbrain sites in rats. One site was the dorsal central gray area (DCG), where electrical stimulation produced frantic, escape-seeking behavior which grossly appeared fear-like and/or pain-like. The other site was in the ventral reticular formation (VRF), where stimulation produced a stereotyped circling response. Stimulation at both sites was aversive in that these animals would bar press for escape in a decremental bar-pressing paradigm. In this paradigm, each bar press decremented the current by five per cent of the initial current level. Following the acquisition of stable baseline decremental bar-pressing performance, animals were given injections of either the serotonin-depleting drug, para-chlorophenylalanine (PCPA), or the catecholamine-depleting drug, alpha-methyl-para-tyrosine (AMPT). Control animals received normal saline. Compared to saline control animals, PCPA-injected DCG-stimulated animals showed a marked change. AMPT-injected VRF-stimulated animals showed a marked decrease in decremental bar pressing, but the DCG-stimulated animals were not affected. These results suggest that escape behavior from electrical stimulation of midbrain sites is mediated by more than one neural system.

AB - Chronic stimulating electrodes were implanted into two separate midbrain sites in rats. One site was the dorsal central gray area (DCG), where electrical stimulation produced frantic, escape-seeking behavior which grossly appeared fear-like and/or pain-like. The other site was in the ventral reticular formation (VRF), where stimulation produced a stereotyped circling response. Stimulation at both sites was aversive in that these animals would bar press for escape in a decremental bar-pressing paradigm. In this paradigm, each bar press decremented the current by five per cent of the initial current level. Following the acquisition of stable baseline decremental bar-pressing performance, animals were given injections of either the serotonin-depleting drug, para-chlorophenylalanine (PCPA), or the catecholamine-depleting drug, alpha-methyl-para-tyrosine (AMPT). Control animals received normal saline. Compared to saline control animals, PCPA-injected DCG-stimulated animals showed a marked change. AMPT-injected VRF-stimulated animals showed a marked decrease in decremental bar pressing, but the DCG-stimulated animals were not affected. These results suggest that escape behavior from electrical stimulation of midbrain sites is mediated by more than one neural system.

UR - http://www.scopus.com/inward/record.url?scp=0017857742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017857742&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(78)91026-0

DO - 10.1016/0006-8993(78)91026-0

M3 - Article

C2 - 150878

AN - SCOPUS:0017857742

VL - 155

SP - 331

EP - 342

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -