Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging

Hao Huang, Rong Xue, Jiangyang Zhang, Tianbo Ren, Linda J. Richards, Paul Yarowsky, Michael I. Miller, Susumu Mori

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

The human brain is extraordinarily complex, and yet its origin is a simple tubular structure. Characterizing its anatomy at different stages of human fetal brain development not only aids in understanding this highly ordered process but also provides clues to detecting abnormalities caused by genetic or environmental factors. During the second trimester of human fetal development, neural structures in the brain undergo significant morphological changes. Diffusion tensor imaging (DTI), a novel method of magnetic resonance imaging, is capable of delineating anatomical components with high contrast and revealing structures at the microscopic level. In this study, high-resolution and high-signal-to-noise-ratio DTI data of fixed tissues of second-trimester human fetal brains were acquired and analyzed. DTI color maps and tractography revealed that important white matter tracts, such as the corpus callosum and uncinate and inferior longitudinal fasciculi, become apparent during this period. Three-dimensional reconstruction shows that major brain fissures appear while most of the cerebral surface remains smooth until the end of the second trimester. A dominant radial organization was identified at 15 gestational weeks, followed by both laminar and radial architectures in the cerebral wall throughout the remainder of the second trimester. Volumetric measurements of different structures indicate that the volumes of basal ganglia and ganglionic eminence increase along with that of the whole brain, while the ventricle size decreases in the later second trimester. The developing fetal brain DTI database presented can be used for education, as an anatomical research reference, and for data registration.

Original languageEnglish (US)
Pages (from-to)4263-4273
Number of pages11
JournalJournal of Neuroscience
Volume29
Issue number13
DOIs
StatePublished - Apr 1 2009

Fingerprint

Diffusion Magnetic Resonance Imaging
Fetal Development
Second Pregnancy Trimester
Diffusion Tensor Imaging
Brain
Corpus Callosum
Signal-To-Noise Ratio
Human Development
Basal Ganglia
Anatomy
Color
Magnetic Resonance Imaging
Databases
Education
Research

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging. / Huang, Hao; Xue, Rong; Zhang, Jiangyang; Ren, Tianbo; Richards, Linda J.; Yarowsky, Paul; Miller, Michael I.; Mori, Susumu.

In: Journal of Neuroscience, Vol. 29, No. 13, 01.04.2009, p. 4263-4273.

Research output: Contribution to journalArticle

Huang, H, Xue, R, Zhang, J, Ren, T, Richards, LJ, Yarowsky, P, Miller, MI & Mori, S 2009, 'Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging', Journal of Neuroscience, vol. 29, no. 13, pp. 4263-4273. https://doi.org/10.1523/JNEUROSCI.2769-08.2009
Huang, Hao ; Xue, Rong ; Zhang, Jiangyang ; Ren, Tianbo ; Richards, Linda J. ; Yarowsky, Paul ; Miller, Michael I. ; Mori, Susumu. / Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging. In: Journal of Neuroscience. 2009 ; Vol. 29, No. 13. pp. 4263-4273.
@article{4005429d0c214011b692f50658d93d04,
title = "Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging",
abstract = "The human brain is extraordinarily complex, and yet its origin is a simple tubular structure. Characterizing its anatomy at different stages of human fetal brain development not only aids in understanding this highly ordered process but also provides clues to detecting abnormalities caused by genetic or environmental factors. During the second trimester of human fetal development, neural structures in the brain undergo significant morphological changes. Diffusion tensor imaging (DTI), a novel method of magnetic resonance imaging, is capable of delineating anatomical components with high contrast and revealing structures at the microscopic level. In this study, high-resolution and high-signal-to-noise-ratio DTI data of fixed tissues of second-trimester human fetal brains were acquired and analyzed. DTI color maps and tractography revealed that important white matter tracts, such as the corpus callosum and uncinate and inferior longitudinal fasciculi, become apparent during this period. Three-dimensional reconstruction shows that major brain fissures appear while most of the cerebral surface remains smooth until the end of the second trimester. A dominant radial organization was identified at 15 gestational weeks, followed by both laminar and radial architectures in the cerebral wall throughout the remainder of the second trimester. Volumetric measurements of different structures indicate that the volumes of basal ganglia and ganglionic eminence increase along with that of the whole brain, while the ventricle size decreases in the later second trimester. The developing fetal brain DTI database presented can be used for education, as an anatomical research reference, and for data registration.",
author = "Hao Huang and Rong Xue and Jiangyang Zhang and Tianbo Ren and Richards, {Linda J.} and Paul Yarowsky and Miller, {Michael I.} and Susumu Mori",
year = "2009",
month = "4",
day = "1",
doi = "10.1523/JNEUROSCI.2769-08.2009",
language = "English (US)",
volume = "29",
pages = "4263--4273",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "13",

}

TY - JOUR

T1 - Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging

AU - Huang, Hao

AU - Xue, Rong

AU - Zhang, Jiangyang

AU - Ren, Tianbo

AU - Richards, Linda J.

AU - Yarowsky, Paul

AU - Miller, Michael I.

AU - Mori, Susumu

PY - 2009/4/1

Y1 - 2009/4/1

N2 - The human brain is extraordinarily complex, and yet its origin is a simple tubular structure. Characterizing its anatomy at different stages of human fetal brain development not only aids in understanding this highly ordered process but also provides clues to detecting abnormalities caused by genetic or environmental factors. During the second trimester of human fetal development, neural structures in the brain undergo significant morphological changes. Diffusion tensor imaging (DTI), a novel method of magnetic resonance imaging, is capable of delineating anatomical components with high contrast and revealing structures at the microscopic level. In this study, high-resolution and high-signal-to-noise-ratio DTI data of fixed tissues of second-trimester human fetal brains were acquired and analyzed. DTI color maps and tractography revealed that important white matter tracts, such as the corpus callosum and uncinate and inferior longitudinal fasciculi, become apparent during this period. Three-dimensional reconstruction shows that major brain fissures appear while most of the cerebral surface remains smooth until the end of the second trimester. A dominant radial organization was identified at 15 gestational weeks, followed by both laminar and radial architectures in the cerebral wall throughout the remainder of the second trimester. Volumetric measurements of different structures indicate that the volumes of basal ganglia and ganglionic eminence increase along with that of the whole brain, while the ventricle size decreases in the later second trimester. The developing fetal brain DTI database presented can be used for education, as an anatomical research reference, and for data registration.

AB - The human brain is extraordinarily complex, and yet its origin is a simple tubular structure. Characterizing its anatomy at different stages of human fetal brain development not only aids in understanding this highly ordered process but also provides clues to detecting abnormalities caused by genetic or environmental factors. During the second trimester of human fetal development, neural structures in the brain undergo significant morphological changes. Diffusion tensor imaging (DTI), a novel method of magnetic resonance imaging, is capable of delineating anatomical components with high contrast and revealing structures at the microscopic level. In this study, high-resolution and high-signal-to-noise-ratio DTI data of fixed tissues of second-trimester human fetal brains were acquired and analyzed. DTI color maps and tractography revealed that important white matter tracts, such as the corpus callosum and uncinate and inferior longitudinal fasciculi, become apparent during this period. Three-dimensional reconstruction shows that major brain fissures appear while most of the cerebral surface remains smooth until the end of the second trimester. A dominant radial organization was identified at 15 gestational weeks, followed by both laminar and radial architectures in the cerebral wall throughout the remainder of the second trimester. Volumetric measurements of different structures indicate that the volumes of basal ganglia and ganglionic eminence increase along with that of the whole brain, while the ventricle size decreases in the later second trimester. The developing fetal brain DTI database presented can be used for education, as an anatomical research reference, and for data registration.

UR - http://www.scopus.com/inward/record.url?scp=65249140137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249140137&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.2769-08.2009

DO - 10.1523/JNEUROSCI.2769-08.2009

M3 - Article

VL - 29

SP - 4263

EP - 4273

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 13

ER -