TY - JOUR
T1 - Androgen-independent prostate cancer is a heterogeneous group of diseases
T2 - Lessons from a rapid autopsy program
AU - Shah, Rajal B.
AU - Mehra, Rohit
AU - Chinnaiyan, Arul M.
AU - Shen, Ronglai
AU - Ghosh, Debashis
AU - Zhou, Ming
AU - MacVicar, Gary R.
AU - Varambally, Soorynarayana
AU - Harwood, Jason
AU - Bismar, Tarek A.
AU - Kim, Robert
AU - Rubin, Mark A.
AU - Pienta, Kenneth J.
PY - 2004/12/15
Y1 - 2004/12/15
N2 - Understanding the biology of prostate cancer metastasis has been limited by the lack of tissue for study. We studied the clinical data, distribution of prostate cancer involvement, morphology, immunophenotypes, and gene expression from 30 rapid autopsies of men who died of hormone-refractory prostate cancer. A tissue microarray was constructed and quantitatively evaluated for expression of prostate-specific antigen, androgen receptor, chromogranin, synaptophysin, MIB-1, and α-methyl-acylCoA-racemase markers. Hierarchical clustering of 16 rapid autopsy tumor samples was performed to evaluate the cDNA expression pattern associated with the morphology. Comparisons were made between patients as well as within the same patient. Metastatic hormone-refractory prostate cancer has a heterogeneous morphology, immunophenotype, and genotype, demonstrating that "metastatic disease" is a group of diseases even within the same patient. An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease.
AB - Understanding the biology of prostate cancer metastasis has been limited by the lack of tissue for study. We studied the clinical data, distribution of prostate cancer involvement, morphology, immunophenotypes, and gene expression from 30 rapid autopsies of men who died of hormone-refractory prostate cancer. A tissue microarray was constructed and quantitatively evaluated for expression of prostate-specific antigen, androgen receptor, chromogranin, synaptophysin, MIB-1, and α-methyl-acylCoA-racemase markers. Hierarchical clustering of 16 rapid autopsy tumor samples was performed to evaluate the cDNA expression pattern associated with the morphology. Comparisons were made between patients as well as within the same patient. Metastatic hormone-refractory prostate cancer has a heterogeneous morphology, immunophenotype, and genotype, demonstrating that "metastatic disease" is a group of diseases even within the same patient. An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease.
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U2 - 10.1158/0008-5472.CAN-04-2442
DO - 10.1158/0008-5472.CAN-04-2442
M3 - Article
C2 - 15604294
AN - SCOPUS:10844235652
SN - 0008-5472
VL - 64
SP - 9209
EP - 9216
JO - Cancer research
JF - Cancer research
IS - 24
ER -