Androgen-independent prostate cancer is a heterogeneous group of diseases: Lessons from a rapid autopsy program

Rajal B. Shah, Rohit Mehra, Arul M. Chinnaiyan, Ronglai Shen, Debashis Ghosh, Ming Zhou, Gary R. MacVicar, Soorynarayana Varambally, Jason Harwood, Tarek A. Bismar, Robert Kim, Mark A. Rubin, Kenneth J. Pienta

Research output: Contribution to journalArticlepeer-review

476 Scopus citations

Abstract

Understanding the biology of prostate cancer metastasis has been limited by the lack of tissue for study. We studied the clinical data, distribution of prostate cancer involvement, morphology, immunophenotypes, and gene expression from 30 rapid autopsies of men who died of hormone-refractory prostate cancer. A tissue microarray was constructed and quantitatively evaluated for expression of prostate-specific antigen, androgen receptor, chromogranin, synaptophysin, MIB-1, and α-methyl-acylCoA-racemase markers. Hierarchical clustering of 16 rapid autopsy tumor samples was performed to evaluate the cDNA expression pattern associated with the morphology. Comparisons were made between patients as well as within the same patient. Metastatic hormone-refractory prostate cancer has a heterogeneous morphology, immunophenotype, and genotype, demonstrating that "metastatic disease" is a group of diseases even within the same patient. An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease.

Original languageEnglish (US)
Pages (from-to)9209-9216
Number of pages8
JournalCancer research
Volume64
Issue number24
DOIs
StatePublished - Dec 15 2004

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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