Androgen insensitivity as a cause of infertility in otherwise normal men

J. Aiman, Jim Griffin III, J. M. Gazak, J. D. Wilson, P. C. MacDonald

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

To ascertain if androgen insensitivity causes severe oligospermia or azoospermia we studied three unrelated, phenotypically normal men with long histories of infertility. The mean plasma concentrations and production rates of testosterone were 14.3 ng per milliliter and 10.1 mg per day, respectively, values approximately twice the average found in normal men. Serum luteinizing hormone concentrations were elevated in two of the three subjects. The specific high-affinity dihydrotestosterone binding capacity of cultured genital-skin fibroblasts was 8, 0 and 10 fmol per milligram of cellular protein, values half (or less) of those from normal men and women but similar to values in subjects with partial androgen insensitivity manifested by incomplete testicular feminization or Reifenstein syndrome. The low amont of androgen receptor and the combination of high serum gonadotropins and plasma testosterone production rates suggest that the defective spermatogenesis in these infertile men was the consequence of androgen insensitivity.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalNew England Journal of Medicine
Volume300
Issue number5
StatePublished - 1979

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Androgen-Insensitivity Syndrome
Infertility
Androgens
Testosterone
Oligospermia
Azoospermia
Dihydrotestosterone
Androgen Receptors
Spermatogenesis
Luteinizing Hormone
Serum
Gonadotropins
Fibroblasts
Skin
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Aiman, J., Griffin III, J., Gazak, J. M., Wilson, J. D., & MacDonald, P. C. (1979). Androgen insensitivity as a cause of infertility in otherwise normal men. New England Journal of Medicine, 300(5), 223-227.

Androgen insensitivity as a cause of infertility in otherwise normal men. / Aiman, J.; Griffin III, Jim; Gazak, J. M.; Wilson, J. D.; MacDonald, P. C.

In: New England Journal of Medicine, Vol. 300, No. 5, 1979, p. 223-227.

Research output: Contribution to journalArticle

Aiman, J, Griffin III, J, Gazak, JM, Wilson, JD & MacDonald, PC 1979, 'Androgen insensitivity as a cause of infertility in otherwise normal men', New England Journal of Medicine, vol. 300, no. 5, pp. 223-227.
Aiman, J. ; Griffin III, Jim ; Gazak, J. M. ; Wilson, J. D. ; MacDonald, P. C. / Androgen insensitivity as a cause of infertility in otherwise normal men. In: New England Journal of Medicine. 1979 ; Vol. 300, No. 5. pp. 223-227.
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