Androgen receptor modulation: Lessons learned from beyond the prostate

Nima Sharifi, William D. Figg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Androgen receptor (AR) is an important transcription factor in prostatic diseases, such as prostate cancer and benign prostatic hyperplasia (BPH). AR regulates the growth and survival of both benign and cancerous prostate epithelial cells. Therefore, modulation of AR function is an important means of treating prostatic diseases. Modern pharmacotherapy for these diseases includes, for example, medical castration and AR antagonists for prostate cancer and 5-α-reductase inhibitors for BPH. However, these treatments have limitations and are illustrated by AR reactivation after medical castration for prostate cancer, commonly termed castrate-resistant prostate cancer. A novel method of AR modulation has been demonstrated in spinal and bulbar muscular atrophy, a disease defined by a polyglutamine repeat expansion which leads to gain-of-function changes in AR and neuromuscular pathology. Here, we examine recent findings from the description of a compound that degrades AR and induces dissociation of AR from an AR coactivator. The biochemistry of this compound may have implications for prostate cancer.

Original languageEnglish (US)
Pages (from-to)1358-1359
Number of pages2
JournalCancer Biology and Therapy
Volume6
Issue number9
StatePublished - Sep 2007

Fingerprint

Androgen Receptors
Prostate
Prostatic Neoplasms
Prostatic Diseases
Castration
Prostatic Hyperplasia
Androgen Receptor Antagonists
Atrophic Muscular Disorders
Biochemistry
Oxidoreductases
Transcription Factors
Epithelial Cells
Pathology
Drug Therapy
Growth

Keywords

  • Androgen receptor
  • Hormonal therapy
  • Prostate cancer
  • Spinal and bulbar muscular atrophy
  • Steroid receptor
  • Testosterone
  • Trinucleotide repeat

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Androgen receptor modulation : Lessons learned from beyond the prostate. / Sharifi, Nima; Figg, William D.

In: Cancer Biology and Therapy, Vol. 6, No. 9, 09.2007, p. 1358-1359.

Research output: Contribution to journalArticle

Sharifi, Nima ; Figg, William D. / Androgen receptor modulation : Lessons learned from beyond the prostate. In: Cancer Biology and Therapy. 2007 ; Vol. 6, No. 9. pp. 1358-1359.
@article{9ec8a3bfbd42463d8269f892825012bc,
title = "Androgen receptor modulation: Lessons learned from beyond the prostate",
abstract = "Androgen receptor (AR) is an important transcription factor in prostatic diseases, such as prostate cancer and benign prostatic hyperplasia (BPH). AR regulates the growth and survival of both benign and cancerous prostate epithelial cells. Therefore, modulation of AR function is an important means of treating prostatic diseases. Modern pharmacotherapy for these diseases includes, for example, medical castration and AR antagonists for prostate cancer and 5-α-reductase inhibitors for BPH. However, these treatments have limitations and are illustrated by AR reactivation after medical castration for prostate cancer, commonly termed castrate-resistant prostate cancer. A novel method of AR modulation has been demonstrated in spinal and bulbar muscular atrophy, a disease defined by a polyglutamine repeat expansion which leads to gain-of-function changes in AR and neuromuscular pathology. Here, we examine recent findings from the description of a compound that degrades AR and induces dissociation of AR from an AR coactivator. The biochemistry of this compound may have implications for prostate cancer.",
keywords = "Androgen receptor, Hormonal therapy, Prostate cancer, Spinal and bulbar muscular atrophy, Steroid receptor, Testosterone, Trinucleotide repeat",
author = "Nima Sharifi and Figg, {William D.}",
year = "2007",
month = "9",
language = "English (US)",
volume = "6",
pages = "1358--1359",
journal = "Cancer Biology and Therapy",
issn = "1538-4047",
publisher = "Landes Bioscience",
number = "9",

}

TY - JOUR

T1 - Androgen receptor modulation

T2 - Lessons learned from beyond the prostate

AU - Sharifi, Nima

AU - Figg, William D.

PY - 2007/9

Y1 - 2007/9

N2 - Androgen receptor (AR) is an important transcription factor in prostatic diseases, such as prostate cancer and benign prostatic hyperplasia (BPH). AR regulates the growth and survival of both benign and cancerous prostate epithelial cells. Therefore, modulation of AR function is an important means of treating prostatic diseases. Modern pharmacotherapy for these diseases includes, for example, medical castration and AR antagonists for prostate cancer and 5-α-reductase inhibitors for BPH. However, these treatments have limitations and are illustrated by AR reactivation after medical castration for prostate cancer, commonly termed castrate-resistant prostate cancer. A novel method of AR modulation has been demonstrated in spinal and bulbar muscular atrophy, a disease defined by a polyglutamine repeat expansion which leads to gain-of-function changes in AR and neuromuscular pathology. Here, we examine recent findings from the description of a compound that degrades AR and induces dissociation of AR from an AR coactivator. The biochemistry of this compound may have implications for prostate cancer.

AB - Androgen receptor (AR) is an important transcription factor in prostatic diseases, such as prostate cancer and benign prostatic hyperplasia (BPH). AR regulates the growth and survival of both benign and cancerous prostate epithelial cells. Therefore, modulation of AR function is an important means of treating prostatic diseases. Modern pharmacotherapy for these diseases includes, for example, medical castration and AR antagonists for prostate cancer and 5-α-reductase inhibitors for BPH. However, these treatments have limitations and are illustrated by AR reactivation after medical castration for prostate cancer, commonly termed castrate-resistant prostate cancer. A novel method of AR modulation has been demonstrated in spinal and bulbar muscular atrophy, a disease defined by a polyglutamine repeat expansion which leads to gain-of-function changes in AR and neuromuscular pathology. Here, we examine recent findings from the description of a compound that degrades AR and induces dissociation of AR from an AR coactivator. The biochemistry of this compound may have implications for prostate cancer.

KW - Androgen receptor

KW - Hormonal therapy

KW - Prostate cancer

KW - Spinal and bulbar muscular atrophy

KW - Steroid receptor

KW - Testosterone

KW - Trinucleotide repeat

UR - http://www.scopus.com/inward/record.url?scp=42549141645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42549141645&partnerID=8YFLogxK

M3 - Article

C2 - 17881894

AN - SCOPUS:42549141645

VL - 6

SP - 1358

EP - 1359

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

SN - 1538-4047

IS - 9

ER -