Androgen resistance — the clinical and molecular spectrum

Jeffrey S. Flier, Lisa H. Underhill, Jim Griffin III

Research output: Contribution to journalReview article

172 Citations (Scopus)

Abstract

RESISTANCE to the action of androgens, like other forms of hormone resistance, is characterized by partial or complete absence of the usual effects of the hormones and normal or increased hormone production.1 Since androgens are important for normal male sexual development and fertility, defects in androgen action are often associated with abnormal sexual differentiation, infertility, or both. This article reviews the phenotypic variation and the range of molecular defects that have been identified in persons with mutations causing androgen resistance. Male Phenotypic Development During embryogenesis the indifferent gonad in males is converted to a testis in response to a testis-determining.

Original languageEnglish (US)
Pages (from-to)611-618
Number of pages8
JournalNew England Journal of Medicine
Volume326
Issue number9
DOIs
StatePublished - Feb 27 1992

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Androgens
Hormones
Testis
Sex Differentiation
Sexual Development
Gonads
Infertility
Embryonic Development
Fertility
Mutation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Androgen resistance — the clinical and molecular spectrum. / Flier, Jeffrey S.; Underhill, Lisa H.; Griffin III, Jim.

In: New England Journal of Medicine, Vol. 326, No. 9, 27.02.1992, p. 611-618.

Research output: Contribution to journalReview article

Flier, Jeffrey S. ; Underhill, Lisa H. ; Griffin III, Jim. / Androgen resistance — the clinical and molecular spectrum. In: New England Journal of Medicine. 1992 ; Vol. 326, No. 9. pp. 611-618.
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