Abstract
RESISTANCE to the action of androgens, like other forms of hormone resistance, is characterized by partial or complete absence of the usual effects of the hormones and normal or increased hormone production.1 Since androgens are important for normal male sexual development and fertility, defects in androgen action are often associated with abnormal sexual differentiation, infertility, or both. This article reviews the phenotypic variation and the range of molecular defects that have been identified in persons with mutations causing androgen resistance. Male Phenotypic Development During embryogenesis the indifferent gonad in males is converted to a testis in response to a testis-determining.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 611-618 |
| Number of pages | 8 |
| Journal | New England Journal of Medicine |
| Volume | 326 |
| Issue number | 9 |
| DOIs | |
| State | Published - Feb 27 1992 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Androgen resistance — the clinical and molecular spectrum. / Flier, Jeffrey S.; Underhill, Lisa H.; Griffin III, Jim.
In: New England Journal of Medicine, Vol. 326, No. 9, 27.02.1992, p. 611-618.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Androgen resistance — the clinical and molecular spectrum
AU - Flier, Jeffrey S.
AU - Underhill, Lisa H.
AU - Griffin III, Jim
PY - 1992/2/27
Y1 - 1992/2/27
N2 - RESISTANCE to the action of androgens, like other forms of hormone resistance, is characterized by partial or complete absence of the usual effects of the hormones and normal or increased hormone production.1 Since androgens are important for normal male sexual development and fertility, defects in androgen action are often associated with abnormal sexual differentiation, infertility, or both. This article reviews the phenotypic variation and the range of molecular defects that have been identified in persons with mutations causing androgen resistance. Male Phenotypic Development During embryogenesis the indifferent gonad in males is converted to a testis in response to a testis-determining.
AB - RESISTANCE to the action of androgens, like other forms of hormone resistance, is characterized by partial or complete absence of the usual effects of the hormones and normal or increased hormone production.1 Since androgens are important for normal male sexual development and fertility, defects in androgen action are often associated with abnormal sexual differentiation, infertility, or both. This article reviews the phenotypic variation and the range of molecular defects that have been identified in persons with mutations causing androgen resistance. Male Phenotypic Development During embryogenesis the indifferent gonad in males is converted to a testis in response to a testis-determining.
UR - http://www.scopus.com/inward/record.url?scp=0026544312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026544312&partnerID=8YFLogxK
U2 - 10.1056/NEJM199202273260906
DO - 10.1056/NEJM199202273260906
M3 - Review article
C2 - 1734252
AN - SCOPUS:0026544312
VL - 326
SP - 611
EP - 618
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 9
ER -