Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging

Research output: Contribution to journalArticle

Abstract

We have examined the endogenous nuclease activity of the liver of intact, castrated and testosterone-treated mice of different ages. Both Mg2+- and Ca2+-dependent endogenous nuclease activities decline in old age. Withdrawal of the hormone increases activity in the immature and young. However, testosterone administration prevents the digestion of nuclei to different extents in all ages. These findings suggest a possible protective role of testosterone in the cleavage of liver chromatin by endogenous nucleases during the aging of mice.

Original languageEnglish (US)
Pages (from-to)59-61
Number of pages3
JournalMolecular Biology Reports
Volume22
Issue number1
StatePublished - 1996

Fingerprint

Liver
Androgens
Chromatin
Testosterone
Aging of materials
Digestion
Hormones

Keywords

  • aging
  • androgen
  • endogenous nuclease
  • mice liver

ASJC Scopus subject areas

  • Genetics
  • Cell Biology
  • Biochemistry

Cite this

Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging. / Mukherjee, S.; Asaithambi, A.; Thakur, M. K.

In: Molecular Biology Reports, Vol. 22, No. 1, 1996, p. 59-61.

Research output: Contribution to journalArticle

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