Androgenetic alopecia at various ages and prostate cancer risk in an equal-access multiethnic case-control series of veterans

Jean Alfred Thomas, Jodi A. Antonelli, Lionel L. Banez, Catherine Hoyo, Delores Grant, Wendy Demark-Wahnefried, Elizabeth A. Platz, Leah Gerber, Kathryn Shuler, Enwono Eyoh, Elizabeth Calloway, Stephen J. Freedland

Research output: Contribution to journalArticle

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Abstract

Purpose Epidemiological data are conflicting regarding the association between androgenetic alopecia (AA) and prostate cancer (CaP). We examined the relationship between these two conditions. Materials and methods We performed a case-control study at a Veterans Affairs Hospital among 708 men: 312 healthy controls, 167 men with CaP, and 229 men without CaP on prostate biopsy. Participants were asked to selfdescribe hair patterns at ages 30 and 40 and at study enrollment. We tested the association between hair pattern (overall, vertex, or frontal) and CaP status using logistic regression analysis adjusting for multiple clinical features. Disease grade was similarly examined as a secondary outcome. Results Relative to healthy controls, younger age of AA onset was significantly associated with increased CaP risk (p = 0.008). Similar patterns were noted for frontal (p = 0.005) and not vertex balding (p = 0.22). When compared with biopsy-negative men, a similar pattern was seen with younger age of AA onset having higher risk of CaP, though this was not significant (p = 0.07). A suggestion for younger age of AA onset for frontal (p = 0.07) being associated with CaP versus biopsy-negative men was also observed. Overall balding (yes/no) was associated with greater than twofold increase in high-grade disease (p = 0.02). Conclusions Men reporting earlier AA onset were at increased CaP risk and suggestively had more aggressive disease. Contrary to other studies, frontal balding was the predominant pattern associated with elevated CaP risk. Further study is required to confirm these findings in a larger sample and to better understand the role of AA, androgens, and CaP biology.

Original languageEnglish (US)
Pages (from-to)1045-1052
Number of pages8
JournalCancer Causes and Control
Volume24
Issue number5
DOIs
StatePublished - May 2013

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Alopecia
Veterans
Prostatic Neoplasms
Biopsy
Hair
Veterans Hospitals
Androgens
Case-Control Studies
Prostate
Logistic Models
Regression Analysis

Keywords

  • Androgenetic alopecia
  • High-grade disease
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Androgenetic alopecia at various ages and prostate cancer risk in an equal-access multiethnic case-control series of veterans. / Thomas, Jean Alfred; Antonelli, Jodi A.; Banez, Lionel L.; Hoyo, Catherine; Grant, Delores; Demark-Wahnefried, Wendy; Platz, Elizabeth A.; Gerber, Leah; Shuler, Kathryn; Eyoh, Enwono; Calloway, Elizabeth; Freedland, Stephen J.

In: Cancer Causes and Control, Vol. 24, No. 5, 05.2013, p. 1045-1052.

Research output: Contribution to journalArticle

Thomas, JA, Antonelli, JA, Banez, LL, Hoyo, C, Grant, D, Demark-Wahnefried, W, Platz, EA, Gerber, L, Shuler, K, Eyoh, E, Calloway, E & Freedland, SJ 2013, 'Androgenetic alopecia at various ages and prostate cancer risk in an equal-access multiethnic case-control series of veterans', Cancer Causes and Control, vol. 24, no. 5, pp. 1045-1052. https://doi.org/10.1007/s10552-013-0182-4
Thomas, Jean Alfred ; Antonelli, Jodi A. ; Banez, Lionel L. ; Hoyo, Catherine ; Grant, Delores ; Demark-Wahnefried, Wendy ; Platz, Elizabeth A. ; Gerber, Leah ; Shuler, Kathryn ; Eyoh, Enwono ; Calloway, Elizabeth ; Freedland, Stephen J. / Androgenetic alopecia at various ages and prostate cancer risk in an equal-access multiethnic case-control series of veterans. In: Cancer Causes and Control. 2013 ; Vol. 24, No. 5. pp. 1045-1052.
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abstract = "Purpose Epidemiological data are conflicting regarding the association between androgenetic alopecia (AA) and prostate cancer (CaP). We examined the relationship between these two conditions. Materials and methods We performed a case-control study at a Veterans Affairs Hospital among 708 men: 312 healthy controls, 167 men with CaP, and 229 men without CaP on prostate biopsy. Participants were asked to selfdescribe hair patterns at ages 30 and 40 and at study enrollment. We tested the association between hair pattern (overall, vertex, or frontal) and CaP status using logistic regression analysis adjusting for multiple clinical features. Disease grade was similarly examined as a secondary outcome. Results Relative to healthy controls, younger age of AA onset was significantly associated with increased CaP risk (p = 0.008). Similar patterns were noted for frontal (p = 0.005) and not vertex balding (p = 0.22). When compared with biopsy-negative men, a similar pattern was seen with younger age of AA onset having higher risk of CaP, though this was not significant (p = 0.07). A suggestion for younger age of AA onset for frontal (p = 0.07) being associated with CaP versus biopsy-negative men was also observed. Overall balding (yes/no) was associated with greater than twofold increase in high-grade disease (p = 0.02). Conclusions Men reporting earlier AA onset were at increased CaP risk and suggestively had more aggressive disease. Contrary to other studies, frontal balding was the predominant pattern associated with elevated CaP risk. Further study is required to confirm these findings in a larger sample and to better understand the role of AA, androgens, and CaP biology.",
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AU - Thomas, Jean Alfred

AU - Antonelli, Jodi A.

AU - Banez, Lionel L.

AU - Hoyo, Catherine

AU - Grant, Delores

AU - Demark-Wahnefried, Wendy

AU - Platz, Elizabeth A.

AU - Gerber, Leah

AU - Shuler, Kathryn

AU - Eyoh, Enwono

AU - Calloway, Elizabeth

AU - Freedland, Stephen J.

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N2 - Purpose Epidemiological data are conflicting regarding the association between androgenetic alopecia (AA) and prostate cancer (CaP). We examined the relationship between these two conditions. Materials and methods We performed a case-control study at a Veterans Affairs Hospital among 708 men: 312 healthy controls, 167 men with CaP, and 229 men without CaP on prostate biopsy. Participants were asked to selfdescribe hair patterns at ages 30 and 40 and at study enrollment. We tested the association between hair pattern (overall, vertex, or frontal) and CaP status using logistic regression analysis adjusting for multiple clinical features. Disease grade was similarly examined as a secondary outcome. Results Relative to healthy controls, younger age of AA onset was significantly associated with increased CaP risk (p = 0.008). Similar patterns were noted for frontal (p = 0.005) and not vertex balding (p = 0.22). When compared with biopsy-negative men, a similar pattern was seen with younger age of AA onset having higher risk of CaP, though this was not significant (p = 0.07). A suggestion for younger age of AA onset for frontal (p = 0.07) being associated with CaP versus biopsy-negative men was also observed. Overall balding (yes/no) was associated with greater than twofold increase in high-grade disease (p = 0.02). Conclusions Men reporting earlier AA onset were at increased CaP risk and suggestively had more aggressive disease. Contrary to other studies, frontal balding was the predominant pattern associated with elevated CaP risk. Further study is required to confirm these findings in a larger sample and to better understand the role of AA, androgens, and CaP biology.

AB - Purpose Epidemiological data are conflicting regarding the association between androgenetic alopecia (AA) and prostate cancer (CaP). We examined the relationship between these two conditions. Materials and methods We performed a case-control study at a Veterans Affairs Hospital among 708 men: 312 healthy controls, 167 men with CaP, and 229 men without CaP on prostate biopsy. Participants were asked to selfdescribe hair patterns at ages 30 and 40 and at study enrollment. We tested the association between hair pattern (overall, vertex, or frontal) and CaP status using logistic regression analysis adjusting for multiple clinical features. Disease grade was similarly examined as a secondary outcome. Results Relative to healthy controls, younger age of AA onset was significantly associated with increased CaP risk (p = 0.008). Similar patterns were noted for frontal (p = 0.005) and not vertex balding (p = 0.22). When compared with biopsy-negative men, a similar pattern was seen with younger age of AA onset having higher risk of CaP, though this was not significant (p = 0.07). A suggestion for younger age of AA onset for frontal (p = 0.07) being associated with CaP versus biopsy-negative men was also observed. Overall balding (yes/no) was associated with greater than twofold increase in high-grade disease (p = 0.02). Conclusions Men reporting earlier AA onset were at increased CaP risk and suggestively had more aggressive disease. Contrary to other studies, frontal balding was the predominant pattern associated with elevated CaP risk. Further study is required to confirm these findings in a larger sample and to better understand the role of AA, androgens, and CaP biology.

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