Anemia blunts the thermogenic response to environmental cold stress in newborn piglets

S. R. Mayfield, P. W. Shaul, W. Oh, B. S. Stonestreet

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We tested the hypothesis that isovolemic anemia blunts the thermogenic response to environmental cold stress in 3 to 4-day-old newborn piglets. Eight animals were studied in both thermoneutral (31.6-32.8° C) and cold (19.6-20.2° C) environments, before and after an isovolemic, partial volume exchange transfusion which reduced the hematocrit from 26 to 15%. In the nonanemic phase of study, deep rectal temperatures declined but had plateaued by 30 minutes after onset of cold stress and remained within normal limits for newborn piglets. In the anemic phase of study, deep rectal temperature declined continuously throughout cold stress with true body core hypothermia (<38° C) observed at all measurement points beyond 15 min of cold stress. Baseline oxygen consumption did not differ between the two study phases (17.6 ± 1.8 versus 16.7 ± 2.1 ml/kg-1/min-1, mean ± SEM). However, during environmental cold stress, oxygen consumption increased by 64% over baseline in the nonanemic phase of study (p < 0.05) whereas 21% increase over baseline was observed in the anemic phase (p NS). We conclude that isovolemic anemia limited oxygen consumption and heat production during environmental cold stress, resulting in body core hypothermia.

Original languageEnglish (US)
Pages (from-to)482-486
Number of pages5
JournalPediatric Research
Volume21
Issue number5
StatePublished - 1987

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Anemia
Oxygen Consumption
Hypothermia
Temperature
Thermogenesis
Hematocrit

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Anemia blunts the thermogenic response to environmental cold stress in newborn piglets. / Mayfield, S. R.; Shaul, P. W.; Oh, W.; Stonestreet, B. S.

In: Pediatric Research, Vol. 21, No. 5, 1987, p. 482-486.

Research output: Contribution to journalArticle

Mayfield, SR, Shaul, PW, Oh, W & Stonestreet, BS 1987, 'Anemia blunts the thermogenic response to environmental cold stress in newborn piglets', Pediatric Research, vol. 21, no. 5, pp. 482-486.
Mayfield, S. R. ; Shaul, P. W. ; Oh, W. ; Stonestreet, B. S. / Anemia blunts the thermogenic response to environmental cold stress in newborn piglets. In: Pediatric Research. 1987 ; Vol. 21, No. 5. pp. 482-486.
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