Abstract
Objective: The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women. Study Design: We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay. Results: Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks' gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk. Conclusions: In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.
Original language | English (US) |
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Pages (from-to) | 244.e1-244.e8 |
Journal | American journal of obstetrics and gynecology |
Volume | 197 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2007 |
Keywords
- angiogenic factors
- placental growth factor
- preeclampsia
- soluble fms-like tyrosine kinase-1
ASJC Scopus subject areas
- Obstetrics and Gynecology