Angiogenic factors for the prediction of preeclampsia in high-risk women

Tiffany A. Moore Simas, Sybil L. Crawford, Matthew J. Solitro, Sara C. Frost, Bruce A. Meyer, Sharon E. Maynard

Research output: Contribution to journalArticle

138 Scopus citations


Objective: The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women. Study Design: We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay. Results: Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks' gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk. Conclusions: In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)244.e1-244.e8
JournalAmerican journal of obstetrics and gynecology
Issue number3
StatePublished - Sep 2007



  • angiogenic factors
  • placental growth factor
  • preeclampsia
  • soluble fms-like tyrosine kinase-1

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Moore Simas, T. A., Crawford, S. L., Solitro, M. J., Frost, S. C., Meyer, B. A., & Maynard, S. E. (2007). Angiogenic factors for the prediction of preeclampsia in high-risk women. American journal of obstetrics and gynecology, 197(3), 244.e1-244.e8.