Angiogenic factors for the prediction of preeclampsia in high-risk women

Tiffany A. Moore Simas, Sybil L. Crawford, Matthew J. Solitro, Sara C. Frost, Bruce A. Meyer, Sharon E. Maynard

Research output: Contribution to journalArticle

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Abstract

Objective: The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women. Study Design: We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay. Results: Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks' gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk. Conclusions: In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume197
Issue number3
DOIs
StatePublished - Sep 2007

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Vascular Endothelial Growth Factor Receptor-1
Angiogenesis Inducing Agents
Pre-Eclampsia
Intercellular Signaling Peptides and Proteins
Pregnancy
Serum
Enzyme-Linked Immunosorbent Assay

Keywords

  • angiogenic factors
  • placental growth factor
  • preeclampsia
  • soluble fms-like tyrosine kinase-1

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Angiogenic factors for the prediction of preeclampsia in high-risk women. / Moore Simas, Tiffany A.; Crawford, Sybil L.; Solitro, Matthew J.; Frost, Sara C.; Meyer, Bruce A.; Maynard, Sharon E.

In: American Journal of Obstetrics and Gynecology, Vol. 197, No. 3, 09.2007.

Research output: Contribution to journalArticle

Moore Simas, Tiffany A. ; Crawford, Sybil L. ; Solitro, Matthew J. ; Frost, Sara C. ; Meyer, Bruce A. ; Maynard, Sharon E. / Angiogenic factors for the prediction of preeclampsia in high-risk women. In: American Journal of Obstetrics and Gynecology. 2007 ; Vol. 197, No. 3.
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