Angiogenins: A new class of microbicidal proteins involved in innate immunity

Lora V. Hooper, Thaddeus S. Stappenbeck, Chieu V. Hong, Jeffrey I. Gordon

Research output: Contribution to journalArticle

630 Scopus citations

Abstract

Although angiogenins have been implicated in tumor-associated angiogenesis, their normal physiologic function remains unclear. We show that a previously uncharacterized angiogenin, Ang4, is produced by mouse Paneth cells, is secreted into the gut lumen and has bactericidal activity against intestinal microbes. Ang4 expression is induced by Bacteroides thetaiotaomicron, a predominant member of the gut microflora, revealing a mechanism whereby intestinal commensal bacteria influence gut microbial ecology and shape innate immunity. Furthermore, mouse Ang1 and human angiogenin, circulating proteins induced during inflammation, exhibit microbicidal activity against systemic bacterial and fungal pathogens, suggesting that they contribute to systemic responses to infection.These results establish angiogenins as a family of endogenous antimicrobial proteins.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
JournalNature immunology
Volume4
Issue number3
DOIs
StatePublished - Mar 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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