Angiomatoid fibrous histiocytoma with t(2;22)(q33;q12.2) and ewsr1 gene rearrangement

Lei Shao, Vivekanand Singh, Linda Cooley

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential. The tumor is mostly seen in the deep dermis and subcutis of the lower extremities in children and young adults. Histologically, the tumor forms lobulated sheets of plump round to spindle cells surrounded by a fibrous pseudocapsule and lymphoid cuff. The cytogenetic and molecular hallmarks of AFH are not well defined. Only 4 of 30 reported cases of AFH have had karyotypic information. We present a case of AFH in the inguinal region of a 12-year-old girl. The tumor showed characteristic histological features, t(2;22)(q33;q12.2), and EWSR gene rearrangement by fluorescence in situ hybridization.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalPediatric and Developmental Pathology
Volume12
Issue number2
DOIs
StatePublished - Mar 1 2009
Externally publishedYes

Keywords

  • Angiomatoid fibrous histiocytoma
  • Chromosome
  • EWSR1-CREB1 gene fusion
  • t(2;22)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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