Angiomatoid fibrous histiocytoma with t(2;22)(q33;q12.2) and ewsr1 gene rearrangement

Lei Shao; Vivekanand Singh; Linda Cooley

doi:10.2350/08-04-0460.1

Angiomatoid fibrous histiocytoma with t(2;22)(q33;q12.2) and ewsr1 gene rearrangement

Lei Shao, Vivekanand Singh, Linda Cooley

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential. The tumor is mostly seen in the deep dermis and subcutis of the lower extremities in children and young adults. Histologically, the tumor forms lobulated sheets of plump round to spindle cells surrounded by a fibrous pseudocapsule and lymphoid cuff. The cytogenetic and molecular hallmarks of AFH are not well defined. Only 4 of 30 reported cases of AFH have had karyotypic information. We present a case of AFH in the inguinal region of a 12-year-old girl. The tumor showed characteristic histological features, t(2;22)(q33;q12.2), and EWSR gene rearrangement by fluorescence in situ hybridization.

Original language	English (US)
Pages (from-to)	143-146
Number of pages	4
Journal	Pediatric and Developmental Pathology
Volume	12
Issue number	2
DOIs	https://doi.org/10.2350/08-04-0460.1
State	Published - Mar 2009
Externally published	Yes

Keywords

Angiomatoid fibrous histiocytoma
Chromosome
EWSR1-CREB1 gene fusion
t(2;22)

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.2350/08-04-0460.1

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title = "Angiomatoid fibrous histiocytoma with t(2;22)(q33;q12.2) and ewsr1 gene rearrangement",

abstract = "Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential. The tumor is mostly seen in the deep dermis and subcutis of the lower extremities in children and young adults. Histologically, the tumor forms lobulated sheets of plump round to spindle cells surrounded by a fibrous pseudocapsule and lymphoid cuff. The cytogenetic and molecular hallmarks of AFH are not well defined. Only 4 of 30 reported cases of AFH have had karyotypic information. We present a case of AFH in the inguinal region of a 12-year-old girl. The tumor showed characteristic histological features, t(2;22)(q33;q12.2), and EWSR gene rearrangement by fluorescence in situ hybridization.",

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Angiomatoid fibrous histiocytoma with t(2;22)(q33;q12.2) and ewsr1 gene rearrangement

Abstract

Keywords

ASJC Scopus subject areas

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