Angiotensin-II and endothelin-1 levels in children with renoprival hypertension

L. Seguias, G. Zilleruelo, J. Strauss, C. Abitbol, B. Montane

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Children with end-stage renal disease (ESRD) often remain hypertensive despite bilateral nephrectomy and aggressive fluid removal on hemodialysis. We speculated that an extrarenal source of renin might contribute to the release of "tissular" angiotensin-II (AT-II) generating hypertension in anephric patients. At the same time, experimental evidence supports that peripheral AT-II vasoconstrictive effect is likely mediated by endothelin-1 (ET-1). Thus, it is conceivable that hypertension in ESRD patients may be due, in part, to a cascade involving vascular production and secretion of AT-II and ET-1. In order to establish the relationship between AT-II, ET-1, and blood pressure we performed a pilot study to measure predialysis systolic and diastolic blood pressures (SBP and DBP, respectively) and serum AT-II and ET-1 levels in 12 anephric children receiving hemodialysis. Predialysis AT-II and ET-1 levels were similar in all patients, and neither value correlated with their mean SBP or DBP. In patients with postdialysis hypertension, there was no correlation between predialysis AT-II and ET-1 plasma levels. We therefore find no evidence to suggest that vascular-mediated AT-II and/or ET-1 contributes significantly to hypertension in anephric patients.

Original languageEnglish (US)
Pages (from-to)493-496
Number of pages4
JournalPediatric Nephrology
Volume16
Issue number6
DOIs
StatePublished - 2001

Fingerprint

Endothelin-1
Angiotensin II
Hypertension
Blood Pressure
Chronic Kidney Failure
Blood Vessels
Renal Dialysis
Renoprival hypertension
Nephrectomy
Renin
Serum

Keywords

  • Angiotensin-II
  • Children
  • Endothelin-1
  • Hypertension

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Angiotensin-II and endothelin-1 levels in children with renoprival hypertension. / Seguias, L.; Zilleruelo, G.; Strauss, J.; Abitbol, C.; Montane, B.

In: Pediatric Nephrology, Vol. 16, No. 6, 2001, p. 493-496.

Research output: Contribution to journalArticle

Seguias, L. ; Zilleruelo, G. ; Strauss, J. ; Abitbol, C. ; Montane, B. / Angiotensin-II and endothelin-1 levels in children with renoprival hypertension. In: Pediatric Nephrology. 2001 ; Vol. 16, No. 6. pp. 493-496.
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