Animal models for the study of noninvasive Haemophilus influenzae disease: Pulmonary clearance systems

Eric J. Hansen, Galen B. Toews

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Nontypeable Haemophilus influenzae are increasingly being recognized as an important cause of disease in the lower respiratory tract. Information about the pathogenesis of these infections has been limited until recently by the paucity of experimental animal models for studying the host-parasite interaction in vivo. Three different animal models for investigation of the interaction of nontypeable H. influenzae with the lower respiratory tract have been used: Two involve the evaluation of short-term pulmonary clearance in mice or rats, while a new, long-term infection model in rats mimics the more chronic bronchopulmonary infections sometimes caused by these organisms. Results obtained in these three model systems indicate that both humoral and cellular immune mechanisms are involved in immunity to lower respiratory tract disease due to nontypeable H. influenzae.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume165
Issue number19999
StatePublished - Jun 1992

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Haemophilus influenzae
Lung Diseases
Animal Models
Respiratory System
Infection
Respiratory Tract Diseases
Host-Parasite Interactions
Immunity
Lung

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Animal models for the study of noninvasive Haemophilus influenzae disease : Pulmonary clearance systems. / Hansen, Eric J.; Toews, Galen B.

In: Journal of Infectious Diseases, Vol. 165, No. 19999, 06.1992.

Research output: Contribution to journalArticle

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