Animal models of lupus and lupus nephritis

Yong Du, Soomro Sanam, Krause Kate, Chandra Mohan

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

This article reviews the commonly used murine strains for studying lupus and lupus nephritis, including strains that develop lupus spontaneously, congenic strains, induced models of lupus, as well as genetically engineered mouse models of lupus bearing transgenes or knockouts. The review then summarizes the main cellular and molecular pathways that lead to the pathogenesis of this autoimmune disease, including autoantibodies. Finally, it concludes with therapeutic insights gained from using mouse models of lupus. To sum, much of what we have learned about lupus has arisen from studying mouse models of the disease, and the laboratory mouse continues to be one of the best tools for studying human SLE.

Original languageEnglish (US)
Pages (from-to)2320-2349
Number of pages30
JournalCurrent Pharmaceutical Design
Volume21
Issue number18
StatePublished - May 1 2015

Keywords

  • Animal models
  • Autoantibody
  • Genetics
  • Lupus
  • Nephritis

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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    Du, Y., Sanam, S., Kate, K., & Mohan, C. (2015). Animal models of lupus and lupus nephritis. Current Pharmaceutical Design, 21(18), 2320-2349.