Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

Peter S. Roland; Leonard Rybak; Maureen Hannley; Greg Matz; Michael G. Stewart; Spiros Manolidis; Rick Friedman; Peter Weber; Fred Owens

doi:10.1016/j.otohns.2003.12.008

Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

Peter S. Roland, Leonard Rybak, Maureen Hannley, Greg Matz, Michael G. Stewart, Spiros Manolidis, Rick Friedman, Peter Weber, Fred Owens

Otolaryngology - Head And Neck Surgery

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.

Original language	English (US)
Pages (from-to)	S57-S78
Journal	Otolaryngology - Head and Neck Surgery
Volume	130
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/j.otohns.2003.12.008
State	Published - Mar 2004

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1016/j.otohns.2003.12.008

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abstract = "OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.",

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T1 - Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

AU - Roland, Peter S.

AU - Rybak, Leonard

AU - Hannley, Maureen

AU - Matz, Greg

AU - Stewart, Michael G.

AU - Manolidis, Spiros

AU - Friedman, Rick

AU - Weber, Peter

AU - Owens, Fred

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AB - OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.

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Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

Abstract

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