Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

Peter S. Roland, Leonard Rybak, Maureen Hannley, Greg Matz, Michael G. Stewart, Spiros Manolidis, Rick Friedman, Peter Weber, Fred Owens

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.

Original languageEnglish (US)
JournalOtolaryngology - Head and Neck Surgery
Volume130
Issue number3 SUPPL.
DOIs
StatePublished - Mar 2004

Fingerprint

Anti-Bacterial Agents
Aminoglycosides
Middle Ear
MEDLINE

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Roland, P. S., Rybak, L., Hannley, M., Matz, G., Stewart, M. G., Manolidis, S., ... Owens, F. (2004). Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. Otolaryngology - Head and Neck Surgery, 130(3 SUPPL.). https://doi.org/10.1016/j.otohns.2003.12.008

Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. / Roland, Peter S.; Rybak, Leonard; Hannley, Maureen; Matz, Greg; Stewart, Michael G.; Manolidis, Spiros; Friedman, Rick; Weber, Peter; Owens, Fred.

In: Otolaryngology - Head and Neck Surgery, Vol. 130, No. 3 SUPPL., 03.2004.

Research output: Contribution to journalArticle

Roland, PS, Rybak, L, Hannley, M, Matz, G, Stewart, MG, Manolidis, S, Friedman, R, Weber, P & Owens, F 2004, 'Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects', Otolaryngology - Head and Neck Surgery, vol. 130, no. 3 SUPPL.. https://doi.org/10.1016/j.otohns.2003.12.008
Roland, Peter S. ; Rybak, Leonard ; Hannley, Maureen ; Matz, Greg ; Stewart, Michael G. ; Manolidis, Spiros ; Friedman, Rick ; Weber, Peter ; Owens, Fred. / Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. In: Otolaryngology - Head and Neck Surgery. 2004 ; Vol. 130, No. 3 SUPPL.
@article{c61907b9a39b400386960c185f676a5d,
title = "Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects",
abstract = "OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.",
author = "Roland, {Peter S.} and Leonard Rybak and Maureen Hannley and Greg Matz and Stewart, {Michael G.} and Spiros Manolidis and Rick Friedman and Peter Weber and Fred Owens",
year = "2004",
month = "3",
doi = "10.1016/j.otohns.2003.12.008",
language = "English (US)",
volume = "130",
journal = "Otolaryngology - Head and Neck Surgery (United States)",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "3 SUPPL.",

}

TY - JOUR

T1 - Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

AU - Roland, Peter S.

AU - Rybak, Leonard

AU - Hannley, Maureen

AU - Matz, Greg

AU - Stewart, Michael G.

AU - Manolidis, Spiros

AU - Friedman, Rick

AU - Weber, Peter

AU - Owens, Fred

PY - 2004/3

Y1 - 2004/3

N2 - OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.

AB - OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.

UR - http://www.scopus.com/inward/record.url?scp=1842427808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842427808&partnerID=8YFLogxK

U2 - 10.1016/j.otohns.2003.12.008

DO - 10.1016/j.otohns.2003.12.008

M3 - Article

C2 - 15054364

AN - SCOPUS:1842427808

VL - 130

JO - Otolaryngology - Head and Neck Surgery (United States)

JF - Otolaryngology - Head and Neck Surgery (United States)

SN - 0194-5998

IS - 3 SUPPL.

ER -