Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome


Research output: Contribution to journalReview article

4 Scopus citations


Radiologically isolated syndrome (RIS) was defined in 2009 for asymptomatic patients who presented incidentally identified white matter anomalies within the central nervous system suggestive of multiple sclerosis (MS). Approximately one-third of RIS subjects will have a seminal clinical demyelinating event within 5 years of the identification of their abnormal MRI. Clinical evolution mirrors relapsing remitting or progressive forms of MS. Pejorative factors for clinical conversion are male gender, age younger than 35 years, and spinal cord lesions.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalNeurologic Clinics
Issue number1
Publication statusPublished - Feb 1 2018



  • Clinically isolated syndrome
  • Incidental findings
  • MRI
  • Multiple sclerosis
  • Radiologically isolated syndrome

ASJC Scopus subject areas

  • Clinical Neurology

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