Antenatal magnesium treatment and neonatal illness severity as measured by the Score for Neonatal Acute Physiology (SNAP)

Shad H. Deering, Amy R. Stagg, Catherine Y. Spong, Kabir Abubakar, John C. Pezzullo, Alessandro Ghidini

Research output: Contribution to journalReview article

6 Scopus citations


Objective. To determine if antepartum administration of magnesium sulfate affects the Score for Neonatal Acute Physiology (SNAP). Methods. We reviewed a database of consecutive preterm admissions to our neonatal intensive care unit over a 12-month period. Information on delivery indication, magnesium sulfate use, betamethasone administration, neonatal SNAP scores, neonatal serum magnesium levels, and other data was collected. Data was analyzed by Chi-square, Student t-test, and multiple linear regression with P < 0.05 considered significant. Results. During the study period, 221 cases fulfilled inclusion and exclusion criteria. Multiple regression revealed a significant association between antepartum magnesium use and improved SNAP scores after controlling for gestational age, glucocorticoid use, chorioamnionitis, and birthweight (SNAP score reduction = -2.25 ± 0.78, P = 0.005). Conclusions. Antepartum administration of magnesium sulfate results in a significant improvement in the neonatal SNAP score. These results suggest that antepartum magnesium sulfate may be protective, or at least not detrimental to the newborn infant.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number2
StatePublished - Feb 2005



  • Antepartum
  • Magnesium sulfate
  • SNAP

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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