Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass

John F. Madden, James L. Burchette, Ganesh V. Raj, John T. Daly, Myron Tannenbaum

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Gastrointestinal stromal tumors (GIST) of the anterior rectal wall can present as a prostatic mass, with concomitant obstructive symptoms. Transrectal biopsies of GIST may be misdiagnosed as primary prostatic sarcomas. We report 3 cases of GIST that were initially characterized as prostatic leiomyosarcomas and treated definitively with pelvic exenteration. The correct diagnosis was possible only after immunohistochemical staining for CD117 and was made retrospectively in 2 of 3 cases. Additional therapy with imatinib (Gleevec™, Novartis Pharmaceuticals Corporation, East Hanover, NJ), an inhibitor of CD117 tyrosine kinase activity, treated recurrence in one patient and effected complete remission.

Original languageEnglish (US)
Pages (from-to)268-272
Number of pages5
JournalUrologic Oncology: Seminars and Original Investigations
Volume23
Issue number4
DOIs
StatePublished - Jul 2005

Keywords

  • Gastrointestinal stromal tumor
  • Gleevec
  • Imatinib
  • Prostatic neoplasms
  • Sarcoma

ASJC Scopus subject areas

  • Oncology
  • Urology

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