Anthraquinones from a marine-derived streptomyces spinoverrucosus

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)anthra[9,1- de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 μM and exhibited moderate cytotoxicity against non-small-cell lung cancer (NSCLC) cell lines Calu-3 and H2887.

Original languageEnglish (US)
Pages (from-to)1759-1764
Number of pages6
JournalJournal of Natural Products
Volume75
Issue number10
DOIs
StatePublished - Oct 26 2012

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Anthraquinones
Streptomyces
Epigenomics
Cells
Spectroscopic analysis
Cytotoxicity
Non-Small Cell Lung Carcinoma
Artifacts
Assays
Nuclear magnetic resonance
Cell Line
heparinized hydrophilic polymer

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Anthraquinones from a marine-derived streptomyces spinoverrucosus. / Hu, Youcai; Martinez, Elisabeth D.; MacMillan, John B.

In: Journal of Natural Products, Vol. 75, No. 10, 26.10.2012, p. 1759-1764.

Research output: Contribution to journalArticle

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