Anthrax mounts a nuclear attack on glucocorticoid signaling

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Anthrax causes profound inflammation and systemic shock. A recent study has shown that anthrax lethal toxin represses the transcriptional activity of the glucocorticoid receptor, which is a crucial component of the body's defenses against inflammation. The study reports evidence that lethal toxin blocks the glucocorticoid receptor by inhibiting the p38 mitogen-activated protein kinase pathway. Thus, these findings suggest that glucocorticoid receptor inactivation contributes to anthrax toxicity and raise the possibility of developing new strategies to combat this deadly disease.

Original languageEnglish (US)
Pages (from-to)558-559
Number of pages2
JournalTrends in Pharmacological Sciences
Volume24
Issue number11
DOIs
StatePublished - Nov 2003

Fingerprint

Anthrax
Glucocorticoid Receptors
Glucocorticoids
Inflammation
p38 Mitogen-Activated Protein Kinases
Toxicity
Shock

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Anthrax mounts a nuclear attack on glucocorticoid signaling. / Kliewer, Steven A.

In: Trends in Pharmacological Sciences, Vol. 24, No. 11, 11.2003, p. 558-559.

Research output: Contribution to journalArticle

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