Anthrax mounts a nuclear attack on glucocorticoid signaling

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

Anthrax causes profound inflammation and systemic shock. A recent study has shown that anthrax lethal toxin represses the transcriptional activity of the glucocorticoid receptor, which is a crucial component of the body's defenses against inflammation. The study reports evidence that lethal toxin blocks the glucocorticoid receptor by inhibiting the p38 mitogen-activated protein kinase pathway. Thus, these findings suggest that glucocorticoid receptor inactivation contributes to anthrax toxicity and raise the possibility of developing new strategies to combat this deadly disease.

Original languageEnglish (US)
Pages (from-to)558-559
Number of pages2
JournalTrends in Pharmacological Sciences
Volume24
Issue number11
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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