Anthropometric factors in relation to risk of glioma

Rebecca B. Little, Melissa H. Madden, Reid C. Thompson, Jeffrey J. Olson, Renato V. LaRocca, Edward Pan, James E. Browning, Kathleen M. Egan, L. Burton Nabors

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction Increased height and greater adiposity have been linked to an increased risk of many cancer types, though few large studies have examined these associations in glioma. We examined body weight and height as potential risk factors for glioma in a large US-based case-control study. Methods The analysis included 1,111 glioma cases and 1,096 community controls. In a structured interview, participants reported their height and weight at 21 years of age, lowest and highest weight in adulthood, and weight 1-5 years in the past. Results Being underweight at age 21 (BMI<18.5 kg/m2) was inversely associated with the risk of glioma development. This protective association was observed in both men and women, but reached statistical significance in women only (multivariate OR 0.68; 95 % CI 0.48, 0.96). When BMI at age 21 was assessed as a continuous variate, a small but significant increase in risk was observed per unit increase in kg/m2 (OR 1.04; 95 % CI 1.02, 1.07). Adult height, recent body weight, and weight change in adulthood were not associated with glioma risk. All results were similar among never smokers and were consistent after stratifying by glioma subtype. Conclusion The present data suggest that a low body weight in early adulthood is associated with a reduced risk of glioma later in life. Results are consistent with previous studies in showing no material association of glioma risk with usual adult body weight. The present study does not support any association of adult stature with glioma risk.

Original languageEnglish (US)
Pages (from-to)1025-1031
Number of pages7
JournalCancer Causes and Control
Volume24
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Glioma
Body Weight
Weights and Measures
Body Height
Thinness
Adiposity
Case-Control Studies
Interviews

Keywords

  • Anthropometrics
  • BMI
  • Epidemiology
  • Glioblastoma
  • Glioma
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Little, R. B., Madden, M. H., Thompson, R. C., Olson, J. J., LaRocca, R. V., Pan, E., ... Nabors, L. B. (2013). Anthropometric factors in relation to risk of glioma. Cancer Causes and Control, 24(5), 1025-1031. https://doi.org/10.1007/s10552-013-0178-0

Anthropometric factors in relation to risk of glioma. / Little, Rebecca B.; Madden, Melissa H.; Thompson, Reid C.; Olson, Jeffrey J.; LaRocca, Renato V.; Pan, Edward; Browning, James E.; Egan, Kathleen M.; Nabors, L. Burton.

In: Cancer Causes and Control, Vol. 24, No. 5, 05.2013, p. 1025-1031.

Research output: Contribution to journalArticle

Little, RB, Madden, MH, Thompson, RC, Olson, JJ, LaRocca, RV, Pan, E, Browning, JE, Egan, KM & Nabors, LB 2013, 'Anthropometric factors in relation to risk of glioma', Cancer Causes and Control, vol. 24, no. 5, pp. 1025-1031. https://doi.org/10.1007/s10552-013-0178-0
Little RB, Madden MH, Thompson RC, Olson JJ, LaRocca RV, Pan E et al. Anthropometric factors in relation to risk of glioma. Cancer Causes and Control. 2013 May;24(5):1025-1031. https://doi.org/10.1007/s10552-013-0178-0
Little, Rebecca B. ; Madden, Melissa H. ; Thompson, Reid C. ; Olson, Jeffrey J. ; LaRocca, Renato V. ; Pan, Edward ; Browning, James E. ; Egan, Kathleen M. ; Nabors, L. Burton. / Anthropometric factors in relation to risk of glioma. In: Cancer Causes and Control. 2013 ; Vol. 24, No. 5. pp. 1025-1031.
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