Anti-epiligrin cicatricial pemphigoid with antibodies against the γ2 subunit of laminin 5

Hossein C. Nousari, Adrienne Rencic, Roger Hsu, Kim B. Yancey, Grant J. Anhalt

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Cicatricial pemphigoid (CP) is a scarring subepithelial mucocutaneous blistering disease characterized by anti-basement membrane zone autoantibodies. Anti-epiligrin CP is an uncommon variant that has been recently characterized. Severe laryngeal involvement is in, frequently observed in all forms of CP and has been documented in only 2 patients with anti-epiligrin CP. Observations: We report a case of CP exhibiting extensive laryngeal and ocular involvement. Histological, immunofluorescence, and immunoprecipitation studies confirmed the diagnosis of anti-epiligrin CP. Immunoblotting studies demonstrated the presence of antibodies against the α3 and the γ2 subunit of laminin 5. Conclusion: This article expands the diversity of the clinical and immunopathologic features of this newly characterized variant of CP.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalArchives of Dermatology
Volume135
Issue number2
StatePublished - Feb 1999

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Benign Mucous Membrane Pemphigoid
Antibodies
kalinin
Immunoprecipitation
Immunoblotting
Basement Membrane
Autoantibodies
Cicatrix
Fluorescent Antibody Technique

ASJC Scopus subject areas

  • Dermatology

Cite this

Anti-epiligrin cicatricial pemphigoid with antibodies against the γ2 subunit of laminin 5. / Nousari, Hossein C.; Rencic, Adrienne; Hsu, Roger; Yancey, Kim B.; Anhalt, Grant J.

In: Archives of Dermatology, Vol. 135, No. 2, 02.1999, p. 173-176.

Research output: Contribution to journalArticle

Nousari, HC, Rencic, A, Hsu, R, Yancey, KB & Anhalt, GJ 1999, 'Anti-epiligrin cicatricial pemphigoid with antibodies against the γ2 subunit of laminin 5', Archives of Dermatology, vol. 135, no. 2, pp. 173-176.
Nousari, Hossein C. ; Rencic, Adrienne ; Hsu, Roger ; Yancey, Kim B. ; Anhalt, Grant J. / Anti-epiligrin cicatricial pemphigoid with antibodies against the γ2 subunit of laminin 5. In: Archives of Dermatology. 1999 ; Vol. 135, No. 2. pp. 173-176.
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