Anti-inflammatory and antioxidant activity of coumarins designed as potential fluorescent zinc sensors

Dimitra Hadjipavlou-Litina, Christos Kontogiorgis, Eleni Pontiki, Marianna Dakanali, Antonia Akoumianaki, Haralambos E. Katerinopoulos

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A series of coumarin analogs, designed and synthesised as potential fluorescent zinc probes were evaluated for their biological activity as anti-inflammatory and antioxidant agents. The effect of the synthesised compounds on inflammation, using the carrageenin-induced rat paw oedema model, was studied. In general, the compounds were found to be potent anti-inflammatory agents (26.5-64%). Compound 5 was found to interact significantly with 1,1-diphenyl-2-picryl-hydrazyl stable free radical (DPPH) whereas the remainder were inactive in this assay. The compounds inhibit in general the soybean lipoxygenase and scavenge superoxide anion radicals. The anti-inflammatory activity seems to be connected with their reducing activity. Their RM values were determined as an expression of their lipophilicity. Theoretical calculations of their lipophilicity as clog P were performed indicating that only a poor relationship exists between their lipophilicity and anti-inflammatory activity.

Original languageEnglish (US)
Pages (from-to)287-292
Number of pages6
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume22
Issue number3
DOIs
StatePublished - Jun 1 2007

Keywords

  • Anti-inflammatories
  • Antioxidants
  • Carrageenin paw oedema
  • Coumarins

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Anti-inflammatory and antioxidant activity of coumarins designed as potential fluorescent zinc sensors'. Together they form a unique fingerprint.

  • Cite this