Anti-laminin-332 mucous membrane pemphigoid in a 9-year old girl

Estelle Kahn, Allyson Spence Shishido, Kim B. Yancey, Leslie P. Lawley

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mucous membrane pemphigoid (MMP), an autoimmune subepithelial blistering disease that predominantly affects the mucous membranes, is usually diagnosed in elderly adults. Early diagnosis of MMP is crucial because it tends to run a chronic and progressive course with the potential for devastating scarring of the mucous membranes that may lead to blindness and airway compromise. A subtype of MMP, anti-laminin-332 MMP, is a rare blistering disorder in which autoantibodies are directed against laminin-332 (formerly epiligrin), a structural protein of the epidermal basement membrane. Herein we report what we believe to be the youngest patient diagnosed with anti-laminin-332 MMP, a 9-year-old girl with disease affecting only the oral, pharyngeal, and laryngeal mucosa, with no skin involvement.

Original languageEnglish (US)
JournalPediatric Dermatology
Volume31
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Bullous Pemphigoid
Mucous Membrane
Laryngeal Mucosa
Mouth Mucosa
Blindness
kalinin
Basement Membrane
Autoantibodies
Cicatrix
Early Diagnosis
Skin

ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Anti-laminin-332 mucous membrane pemphigoid in a 9-year old girl. / Kahn, Estelle; Spence Shishido, Allyson; Yancey, Kim B.; Lawley, Leslie P.

In: Pediatric Dermatology, Vol. 31, No. 3, 2014.

Research output: Contribution to journalArticle

Kahn, Estelle ; Spence Shishido, Allyson ; Yancey, Kim B. ; Lawley, Leslie P. / Anti-laminin-332 mucous membrane pemphigoid in a 9-year old girl. In: Pediatric Dermatology. 2014 ; Vol. 31, No. 3.
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