Anti-p200 pemphigoid: Diagnosis and treatment of a case presenting as an inflammatory subepidermal blistering disease

Conleth A. Egan, Carole Yee, Detlef Zillikens, Kim B. Yancey

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Anti-p200 pemphigoid is a recently defined subepidermal immunobullous disease. It is characterized by the binding of circulating IgG autoantibodies to the dermal side of 1 M NaCl split skin and by reactivity of these autoantibodies to a unique 200-kd antigen on immunoblot of dermal extract. On immunoelectron microscopic examination, these autoantibodies deposit at the lamina lucida-lamina densa interface. We describe the clinical, histologic, and immunopathologic features in a patient with anti-p200 pemphigoid, as well as his favorable response to treatment with systemic glucocorticosteroids and dapsone.

Original languageEnglish (US)
Pages (from-to)786-789
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume46
Issue number5
DOIs
StatePublished - May 1 2002

ASJC Scopus subject areas

  • Dermatology

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