Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors

R. Krance, H. E. Heslop, H. Mahmoud, R. Ribeiro, E. Douglass, C. Hurwitz, V. Santana, L. Kun, M. M. Horowitz, M. K. Brenner

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Six patients (five children ≤ 12 years old and one young adult) underwent allogeneic BMT (not T lymphocyte-depleted) from sex-matched HLA-identical siblings. GVHD prophylaxis consisted of methylprednisolone (30 mg/m2) and anti pan T lymphocyte ricin A chain immunotoxin (H65-RTA) (0.1 mg/kg) administered daily for 12 consecutive doses. H65 RTA was initiated at day + 5 (n = 4) or day + 2 (n = 2). All patients engrafted. Despite receiving the planned GVHD prophylaxis, all patients developed moderate to severe acute GVHD; five patients developed Grade III/IV GVHD. Four patients died 34 to 78 days post-transplant; GVHD was a contributory cause of death in each case. H65 RTA as used in this study was ineffective for the prophylaxis of acute GVHD.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalBone Marrow Transplantation
Volume11
Issue number1
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Krance, R., Heslop, H. E., Mahmoud, H., Ribeiro, R., Douglass, E., Hurwitz, C., Santana, V., Kun, L., Horowitz, M. M., & Brenner, M. K. (1993). Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors. Bone Marrow Transplantation, 11(1), 33-36.