Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde–Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging

Fang Xie, Fangyu Peng

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Copper 8-hydroxyquinoline-2-carboxaldehyde–thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde–4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Fluorescence
DOIs
StateAccepted/In press - Jun 26 2017

Keywords

  • Anticancer copper complex
  • Green fluorescent protein, fluorescent imaging
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry

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