Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde–Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging

Fang Xie, Fangyu Peng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Copper 8-hydroxyquinoline-2-carboxaldehyde–thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde–4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Fluorescence
DOIs
StateAccepted/In press - Jun 26 2017

Fingerprint

Oxyquinoline
Copper
Prostatic Neoplasms
cancer
Imaging techniques
Cells
Green Fluorescent Proteins
proliferation
Cytotoxicity
Neuroblastoma
Cisplatin
Testing
thiosemicarbazide

Keywords

  • Anticancer copper complex
  • Green fluorescent protein, fluorescent imaging
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry

Cite this

@article{3c481025c0464665960802073a405d32,
title = "Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde–Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging",
abstract = "Copper 8-hydroxyquinoline-2-carboxaldehyde–thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde–4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.",
keywords = "Anticancer copper complex, Green fluorescent protein, fluorescent imaging, Prostate cancer",
author = "Fang Xie and Fangyu Peng",
year = "2017",
month = "6",
day = "26",
doi = "10.1007/s10895-017-2133-z",
language = "English (US)",
pages = "1--5",
journal = "Journal of Fluorescence",
issn = "1053-0509",
publisher = "Springer New York",

}

TY - JOUR

T1 - Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde–Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging

AU - Xie, Fang

AU - Peng, Fangyu

PY - 2017/6/26

Y1 - 2017/6/26

N2 - Copper 8-hydroxyquinoline-2-carboxaldehyde–thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde–4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.

AB - Copper 8-hydroxyquinoline-2-carboxaldehyde–thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde–4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.

KW - Anticancer copper complex

KW - Green fluorescent protein, fluorescent imaging

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=85021290675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021290675&partnerID=8YFLogxK

U2 - 10.1007/s10895-017-2133-z

DO - 10.1007/s10895-017-2133-z

M3 - Article

SP - 1

EP - 5

JO - Journal of Fluorescence

JF - Journal of Fluorescence

SN - 1053-0509

ER -