Anti-virulence strategies to combat bacteria-mediated disease

David A. Rasko, Vanessa Sperandio

Research output: Contribution to journalReview articlepeer-review

927 Scopus citations


Antibiotic resistance is one of the greatest challenges of the twenty-first century. However, the increasing understanding of bacterial pathogenesis and intercellular communication has revealed many potential strategies to develop novel drugs to treat bacteria-mediated disease. Interference with bacterial virulence and/or cell-to-cell signalling pathways is an especially compelling approach, as it is thought to apply less selective pressure for the development of bacterial resistance than traditional strategies, which are aimed at killing bacteria or preventing their growth. Here, we discuss the mechanisms of bacterial virulence and present promising anti-virulence strategies and compounds for the future treatment of bacterial infections.

Original languageEnglish (US)
Pages (from-to)117-128
Number of pages12
JournalNature Reviews Drug Discovery
Issue number2
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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