Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents

Rahul D. Shingare, John B. MacMillan, D. Srinivasa Reddy

Research output: Contribution to journalArticlepeer-review

Abstract

Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.

Original languageEnglish (US)
Article number114245
JournalEuropean Journal of Medicinal Chemistry
Volume236
DOIs
StatePublished - Jun 5 2022
Externally publishedYes

Keywords

  • Antibiotic natural product
  • Hunanamycin A
  • Riboflavin synthase
  • Salmonella
  • Structure activity relationship

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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