Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents

Rahul D. Shingare; John B. MacMillan; D. Srinivasa Reddy

doi:10.1016/j.ejmech.2022.114245

Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents

Rahul D. Shingare, John B. MacMillan, D. Srinivasa Reddy

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.

Original language	English (US)
Article number	114245
Journal	European Journal of Medicinal Chemistry
Volume	236
DOIs	https://doi.org/10.1016/j.ejmech.2022.114245
State	Published - Jun 5 2022

Keywords

Antibiotic natural product
Hunanamycin A
Riboflavin synthase
Salmonella
Structure activity relationship

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Organic Chemistry

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10.1016/j.ejmech.2022.114245

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title = "Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents",

abstract = "Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.",

keywords = "Antibiotic natural product, Hunanamycin A, Riboflavin synthase, Salmonella, Structure activity relationship",

author = "Shingare, {Rahul D.} and MacMillan, {John B.} and Reddy, {D. Srinivasa}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

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doi = "10.1016/j.ejmech.2022.114245",

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AU - Shingare, Rahul D.

AU - MacMillan, John B.

AU - Reddy, D. Srinivasa

PY - 2022/6/5

Y1 - 2022/6/5

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AB - Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.

KW - Antibiotic natural product

KW - Hunanamycin A

KW - Riboflavin synthase

KW - Salmonella

KW - Structure activity relationship

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Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents

Abstract

Keywords

ASJC Scopus subject areas

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