Antibiotic Use in Sexually Transmissible Diseases

Ted Rosen, Travis Vandergriff, Mandy Harting

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Sexually transmissible diseases (STDs) remain a major health issue worldwide, with approximately 300 million new cases annually. STDs caused by bacteria can be treated with antibiotics, although the susceptibility pattern of many etiologic microbes has changed over the past few decades. Syphilis remains best managed with single-dose benzathine penicillin G. Other single-dose antibiotic regimens for lues are either associated with clinical failure or of uncertain dosage. However, single-dose azithromycin and ceftriaxone are suitable for chancroid. Lymphogranuloma venereum, reemergent as a cause of proctitis, is treated with prolonged courses of doxycycline or minocycline. Trimethoprim-sulfamethoxazole has replaced tetracycline derivatives as preferred treatment for donovanosis in many regions. Parenteral cephalosporins, such as ceftriaxone, cefotaxime, and ceftizoxime, are initial interventions for disseminated gonococcemia. Pending culture results, genital bite wounds (often consisting of deep, painful ulcerations) should be treated with high-dose amoxicillin-clavulanic acid.

Original languageEnglish (US)
Pages (from-to)49-61
Number of pages13
JournalDermatologic Clinics
Volume27
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Ceftriaxone
Syphilis
Granuloma Inguinale
Chancroid
Lymphogranuloma Venereum
Ceftizoxime
Penicillin G Benzathine
Proctitis
Anti-Bacterial Agents
Amoxicillin-Potassium Clavulanate Combination
Minocycline
Azithromycin
Cefotaxime
Doxycycline
Sulfamethoxazole Drug Combination Trimethoprim
Bites and Stings
Cephalosporins
Tetracycline
Bacteria
Wounds and Injuries

Keywords

  • Donovanosis
  • Gonorrhea
  • LGV
  • STD
  • Syphilis

ASJC Scopus subject areas

  • Dermatology

Cite this

Antibiotic Use in Sexually Transmissible Diseases. / Rosen, Ted; Vandergriff, Travis; Harting, Mandy.

In: Dermatologic Clinics, Vol. 27, No. 1, 01.2009, p. 49-61.

Research output: Contribution to journalArticle

Rosen, Ted ; Vandergriff, Travis ; Harting, Mandy. / Antibiotic Use in Sexually Transmissible Diseases. In: Dermatologic Clinics. 2009 ; Vol. 27, No. 1. pp. 49-61.
@article{83106415d05d4489a1430860d26ba936,
title = "Antibiotic Use in Sexually Transmissible Diseases",
abstract = "Sexually transmissible diseases (STDs) remain a major health issue worldwide, with approximately 300 million new cases annually. STDs caused by bacteria can be treated with antibiotics, although the susceptibility pattern of many etiologic microbes has changed over the past few decades. Syphilis remains best managed with single-dose benzathine penicillin G. Other single-dose antibiotic regimens for lues are either associated with clinical failure or of uncertain dosage. However, single-dose azithromycin and ceftriaxone are suitable for chancroid. Lymphogranuloma venereum, reemergent as a cause of proctitis, is treated with prolonged courses of doxycycline or minocycline. Trimethoprim-sulfamethoxazole has replaced tetracycline derivatives as preferred treatment for donovanosis in many regions. Parenteral cephalosporins, such as ceftriaxone, cefotaxime, and ceftizoxime, are initial interventions for disseminated gonococcemia. Pending culture results, genital bite wounds (often consisting of deep, painful ulcerations) should be treated with high-dose amoxicillin-clavulanic acid.",
keywords = "Donovanosis, Gonorrhea, LGV, STD, Syphilis",
author = "Ted Rosen and Travis Vandergriff and Mandy Harting",
year = "2009",
month = "1",
doi = "10.1016/j.det.2008.07.002",
language = "English (US)",
volume = "27",
pages = "49--61",
journal = "Dermatologic Clinics",
issn = "0733-8635",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Antibiotic Use in Sexually Transmissible Diseases

AU - Rosen, Ted

AU - Vandergriff, Travis

AU - Harting, Mandy

PY - 2009/1

Y1 - 2009/1

N2 - Sexually transmissible diseases (STDs) remain a major health issue worldwide, with approximately 300 million new cases annually. STDs caused by bacteria can be treated with antibiotics, although the susceptibility pattern of many etiologic microbes has changed over the past few decades. Syphilis remains best managed with single-dose benzathine penicillin G. Other single-dose antibiotic regimens for lues are either associated with clinical failure or of uncertain dosage. However, single-dose azithromycin and ceftriaxone are suitable for chancroid. Lymphogranuloma venereum, reemergent as a cause of proctitis, is treated with prolonged courses of doxycycline or minocycline. Trimethoprim-sulfamethoxazole has replaced tetracycline derivatives as preferred treatment for donovanosis in many regions. Parenteral cephalosporins, such as ceftriaxone, cefotaxime, and ceftizoxime, are initial interventions for disseminated gonococcemia. Pending culture results, genital bite wounds (often consisting of deep, painful ulcerations) should be treated with high-dose amoxicillin-clavulanic acid.

AB - Sexually transmissible diseases (STDs) remain a major health issue worldwide, with approximately 300 million new cases annually. STDs caused by bacteria can be treated with antibiotics, although the susceptibility pattern of many etiologic microbes has changed over the past few decades. Syphilis remains best managed with single-dose benzathine penicillin G. Other single-dose antibiotic regimens for lues are either associated with clinical failure or of uncertain dosage. However, single-dose azithromycin and ceftriaxone are suitable for chancroid. Lymphogranuloma venereum, reemergent as a cause of proctitis, is treated with prolonged courses of doxycycline or minocycline. Trimethoprim-sulfamethoxazole has replaced tetracycline derivatives as preferred treatment for donovanosis in many regions. Parenteral cephalosporins, such as ceftriaxone, cefotaxime, and ceftizoxime, are initial interventions for disseminated gonococcemia. Pending culture results, genital bite wounds (often consisting of deep, painful ulcerations) should be treated with high-dose amoxicillin-clavulanic acid.

KW - Donovanosis

KW - Gonorrhea

KW - LGV

KW - STD

KW - Syphilis

UR - http://www.scopus.com/inward/record.url?scp=54449101842&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54449101842&partnerID=8YFLogxK

U2 - 10.1016/j.det.2008.07.002

DO - 10.1016/j.det.2008.07.002

M3 - Article

VL - 27

SP - 49

EP - 61

JO - Dermatologic Clinics

JF - Dermatologic Clinics

SN - 0733-8635

IS - 1

ER -