Antibodies to polymerized human serum albumin in acute and chronic liver disease

W. M. Lee, L. McLeod, K. Martin, D. L. Emerson, R. M. Galbraith

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of acute and chronic liver diseases with and without HBsAg using an ELISA. The prevalence of circulating polyalbumin antibodies was shown to be significantly increased over that of healthy controls (6.7%) in patients with autoimmune chronic active hepatitis (67%), acute viral hepatitis (41%) and fulminant hepatic necrosis (38%), but such antibodies were absent in chronic hepatitis B patients and other liver diseases. Serial studies in acute hepatitis showed evidence of antibodies early in the course of illness with disappearance prior to full recovery. In acute hepatitis B, the presence of polyalbumin antibodies was significantly associated with female sex (p < 0.01), 3-fold higher transaminase levels and shorter duration of clinical illness (<4 weeks in all cases). Polyalbumin antibodies appear to be associated with diseases characterized by active hepatocyte necrosis. Since they are evident early in acute hepatitis B when complexes of polyalbumin and virus are likely, these antibodies may play an adjunctive role to other hepatitis B-related antibodies in the clearance of hepatitis B virus infection.

Original languageEnglish (US)
Pages (from-to)906-912
Number of pages7
JournalHepatology
Volume7
Issue number5
StatePublished - 1987

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Serum Albumin
Liver Diseases
Chronic Disease
Antibodies
Hepatitis
Hepatitis B
Necrosis
Hepatitis B Antibodies
Autoimmune Hepatitis
Chronic Hepatitis B
Virus Diseases
Chronic Hepatitis
Hepatitis B Surface Antigens
Transaminases
polyalbumin
Hepatitis B virus
Hepatocytes
Fibrosis
Enzyme-Linked Immunosorbent Assay
Viruses

ASJC Scopus subject areas

  • Hepatology

Cite this

Lee, W. M., McLeod, L., Martin, K., Emerson, D. L., & Galbraith, R. M. (1987). Antibodies to polymerized human serum albumin in acute and chronic liver disease. Hepatology, 7(5), 906-912.

Antibodies to polymerized human serum albumin in acute and chronic liver disease. / Lee, W. M.; McLeod, L.; Martin, K.; Emerson, D. L.; Galbraith, R. M.

In: Hepatology, Vol. 7, No. 5, 1987, p. 906-912.

Research output: Contribution to journalArticle

Lee, WM, McLeod, L, Martin, K, Emerson, DL & Galbraith, RM 1987, 'Antibodies to polymerized human serum albumin in acute and chronic liver disease', Hepatology, vol. 7, no. 5, pp. 906-912.
Lee WM, McLeod L, Martin K, Emerson DL, Galbraith RM. Antibodies to polymerized human serum albumin in acute and chronic liver disease. Hepatology. 1987;7(5):906-912.
Lee, W. M. ; McLeod, L. ; Martin, K. ; Emerson, D. L. ; Galbraith, R. M. / Antibodies to polymerized human serum albumin in acute and chronic liver disease. In: Hepatology. 1987 ; Vol. 7, No. 5. pp. 906-912.
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