Antibody-directed targeting of the vasculature of solid tumors

Philip E. Thorpe, Francis J. Burrows

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

An attractive strategy for the therapy of carcinomas and other solid tumors would be to target cytotoxic agents or host immune effectors to the endothelial cells of the tumor vasculature rather than to the tumor cells themselves. The key advantage of this approach is that the endothelial cells are freely accessible through the blood whereas the tumor cells are, for the most part, inaccessible. Also, endothelial cells are similar in different tumors, making it feasible to develop a single reagent for treating numerous types of cancer. In this chapter, we review progress in this "vascular targeting" approach, from the validation of the concept in a mouse model to the characterization of the TEC-11 antibody against endoglin, an endothelial cell proliferation marker that is upregulated on endothelial cells in miscellaneous human solid tumors. In addition, we review other tumor endothelial cell markers that are candidates for vascular targeting in man.

Original languageEnglish (US)
Pages (from-to)237-251
Number of pages15
JournalBreast Cancer Research and Treatment
Volume36
Issue number2
DOIs
StatePublished - Jan 1 1995

Keywords

  • TEC-11 antibody
  • endothelial cells
  • monoclonal antibodies
  • solid tumors
  • therapy
  • vascular targeting

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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