Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing)

H. W. Virgin IV, R. Bassel-Duby, B. N. Fields, K. L. Tyler

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

The mammalian reoviruses have provided a valuable model for studying the pathogenesis of viral infections of the central nervous system (CNS). We have used this model to study the effect of antibody on disease produced by the neurally spreading reovirus type 3 (Dearing) (T3). Polyclonal and monoclonal antibodies protect mice from fatal infection with T3 after either footpad or intracerebral virus challenge. Protection occurs with monoclonal antibodies directed against the viral cell attachment protein sigma 1, and with polyclonal antisera without T3 sigma 1 binding activity. In vivo protection occurs with both neutralizing and nonneutralizing monoclonal antibodies. Antibody-mediated protection does not require serum complement and, under specific circumstances, can occur via Fc-independent mechanisms. Antibody can protect mice when transferred up to 5 days after intracerebral challenge and up to 7 days after footpad challenge, times when high titers of virus are present in the CNS. Thus, antibody mediated protection against this neurally spreading virus does not require neutralizing antibody or serum complement and occurs even in the face of established CNS infection.

Original languageEnglish (US)
Pages (from-to)4594-4604
Number of pages11
JournalJournal of Virology
Volume62
Issue number12
StatePublished - 1988

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Mammalian orthoreovirus 3
Reoviridae
central nervous system
monoclonal antibodies
antibodies
Antibodies
Monoclonal Antibodies
blood serum
Infection
infection
complement
Central Nervous System Viral Diseases
Viruses
Central Nervous System Infections
viruses
mice
viral load
Neutralizing Antibodies
Viral Load
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). / Virgin IV, H. W.; Bassel-Duby, R.; Fields, B. N.; Tyler, K. L.

In: Journal of Virology, Vol. 62, No. 12, 1988, p. 4594-4604.

Research output: Contribution to journalArticle

Virgin IV, H. W. ; Bassel-Duby, R. ; Fields, B. N. ; Tyler, K. L. / Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). In: Journal of Virology. 1988 ; Vol. 62, No. 12. pp. 4594-4604.
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