Antibody response following implantation of xenogenic lenticules

D. R. Willey; E. Maguen; S. Pinhas; Steven Verity; A. B. Nesburn

doi:10.1097/00003226-198401000-00007

Antibody response following implantation of xenogenic lenticules

D. R. Willey, E. Maguen, S. Pinhas, Steven Verity, A. B. Nesburn

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3 Scopus citations

Abstract

Rabbits underwent implantation of either lyophilized or fresh porcine lenticules into the central or peripheral cornea. All animals were followed for up to four months by slit-lamp examination and macrophotography to determine implant rejection. Serum antibody levels to soluble porcine cornea extract were determined by an enzyme-linked immunosorbant assay. Only those animals receiving lenticules into the peripheral cornea experienced a rejection and developed an antibody response to the porcine cornea extract. The production of antibody preceded the appearance of vascularization of the implanted lenticules. Thus, the site of lenticule implantation, not the type of tissue preparation, determined the outcome of the graft.

Original language	English (US)
Pages (from-to)	33-36
Number of pages	4
Journal	Cornea
Volume	3
Issue number	1
DOIs	https://doi.org/10.1097/00003226-198401000-00007
State	Published - 1984

ASJC Scopus subject areas

Ophthalmology

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10.1097/00003226-198401000-00007

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abstract = "Rabbits underwent implantation of either lyophilized or fresh porcine lenticules into the central or peripheral cornea. All animals were followed for up to four months by slit-lamp examination and macrophotography to determine implant rejection. Serum antibody levels to soluble porcine cornea extract were determined by an enzyme-linked immunosorbant assay. Only those animals receiving lenticules into the peripheral cornea experienced a rejection and developed an antibody response to the porcine cornea extract. The production of antibody preceded the appearance of vascularization of the implanted lenticules. Thus, the site of lenticule implantation, not the type of tissue preparation, determined the outcome of the graft.",

author = "Willey, {D. R.} and E. Maguen and S. Pinhas and Steven Verity and Nesburn, {A. B.}",

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T1 - Antibody response following implantation of xenogenic lenticules

AU - Willey, D. R.

AU - Maguen, E.

AU - Pinhas, S.

AU - Verity, Steven

AU - Nesburn, A. B.

PY - 1984

Y1 - 1984

N2 - Rabbits underwent implantation of either lyophilized or fresh porcine lenticules into the central or peripheral cornea. All animals were followed for up to four months by slit-lamp examination and macrophotography to determine implant rejection. Serum antibody levels to soluble porcine cornea extract were determined by an enzyme-linked immunosorbant assay. Only those animals receiving lenticules into the peripheral cornea experienced a rejection and developed an antibody response to the porcine cornea extract. The production of antibody preceded the appearance of vascularization of the implanted lenticules. Thus, the site of lenticule implantation, not the type of tissue preparation, determined the outcome of the graft.

AB - Rabbits underwent implantation of either lyophilized or fresh porcine lenticules into the central or peripheral cornea. All animals were followed for up to four months by slit-lamp examination and macrophotography to determine implant rejection. Serum antibody levels to soluble porcine cornea extract were determined by an enzyme-linked immunosorbant assay. Only those animals receiving lenticules into the peripheral cornea experienced a rejection and developed an antibody response to the porcine cornea extract. The production of antibody preceded the appearance of vascularization of the implanted lenticules. Thus, the site of lenticule implantation, not the type of tissue preparation, determined the outcome of the graft.

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VL - 3

SP - 33

EP - 36

JO - Cornea

JF - Cornea

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ER -

Antibody response following implantation of xenogenic lenticules

Abstract

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