TY - JOUR
T1 - Antibody testing as a diagnostic tool in autonomic disorders.
AU - Vernino, Steven
PY - 2009/2
Y1 - 2009/2
N2 - Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.
AB - Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.
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U2 - 10.1007/s10286-008-0488-6
DO - 10.1007/s10286-008-0488-6
M3 - Review article
C2 - 18726055
AN - SCOPUS:65349128271
SN - 0959-9851
VL - 19
SP - 13
EP - 19
JO - Clinical autonomic research : official journal of the Clinical Autonomic Research Society
JF - Clinical autonomic research : official journal of the Clinical Autonomic Research Society
IS - 1
ER -