Antibody testing as a diagnostic tool in autonomic disorders.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalClinical autonomic research : official journal of the Clinical Autonomic Research Society
Volume19
Issue number1
DOIs
StatePublished - Feb 2009

Fingerprint

Antibodies
Primary Dysautonomias
Intestinal Pseudo-Obstruction
Cholinergic Receptors
Anti-Idiotypic Antibodies
Membranes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{4730f0592c15445893e17c52dddd340a,
title = "Antibody testing as a diagnostic tool in autonomic disorders.",
abstract = "Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.",
author = "Steven Vernino",
year = "2009",
month = "2",
doi = "10.1007/s10286-008-0488-6",
language = "English (US)",
volume = "19",
pages = "13--19",
journal = "Clinical Autonomic Research",
issn = "0959-9851",
publisher = "D. Steinkopff-Verlag",
number = "1",

}

TY - JOUR

T1 - Antibody testing as a diagnostic tool in autonomic disorders.

AU - Vernino, Steven

PY - 2009/2

Y1 - 2009/2

N2 - Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.

AB - Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.

UR - http://www.scopus.com/inward/record.url?scp=65349128271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65349128271&partnerID=8YFLogxK

U2 - 10.1007/s10286-008-0488-6

DO - 10.1007/s10286-008-0488-6

M3 - Article

C2 - 18726055

AN - SCOPUS:65349128271

VL - 19

SP - 13

EP - 19

JO - Clinical Autonomic Research

JF - Clinical Autonomic Research

SN - 0959-9851

IS - 1

ER -