Abstract
Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13-19 |
| Number of pages | 7 |
| Journal | Clinical autonomic research : official journal of the Clinical Autonomic Research Society |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2009 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Antibody testing as a diagnostic tool in autonomic disorders. / Vernino, Steven.
In: Clinical autonomic research : official journal of the Clinical Autonomic Research Society, Vol. 19, No. 1, 02.2009, p. 13-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibody testing as a diagnostic tool in autonomic disorders.
AU - Vernino, Steven
PY - 2009/2
Y1 - 2009/2
N2 - Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.
AB - Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.
UR - http://www.scopus.com/inward/record.url?scp=65349128271&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65349128271&partnerID=8YFLogxK
U2 - 10.1007/s10286-008-0488-6
DO - 10.1007/s10286-008-0488-6
M3 - Article
C2 - 18726055
AN - SCOPUS:65349128271
VL - 19
SP - 13
EP - 19
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
SN - 0959-9851
IS - 1
ER -