Antibody Testing in Atypical Optic Neuritis

Melanie Truong-Le, Bart Chwalisz

Research output: Contribution to journalReview articlepeer-review

Abstract

Optic neuritis (ON) is a common manifestation of central nervous system demyelinating disorders such as multiple sclerosis (MS). The last two decades have seen increasing recognition of atypical optic neuritis syndromes, driven in large part by characterization of demyelinating diseases associated with antibodies to aquaporin 4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG). Given their increased importance in the workup of ON, familiarity with serological tests for ON has become essential for ophthalmologists. This review will discuss technological aspects, performance, and clinical implications of serological tests for atypical ON.

Original languageEnglish (US)
Pages (from-to)287-295
Number of pages9
JournalSeminars in Ophthalmology
Volume35
Issue number5-6
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Atypical optic neuritis
  • CRMP-5 antibody
  • MOG antibody
  • aquaporin-4 antibody
  • neuromyelitis optica spectrum disorder

ASJC Scopus subject areas

  • Ophthalmology

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