Antibody-toxin hybrids: A clinical review of their use

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Immunotoxins are protein molecules composed of monoclonal antibodies linked covalently to either peptide toxins or polypeptides related to toxins. These molecules can be used in the therapy of a number of malignant diseases including lymphoma, leukemia, and solid tumors. They can be used to prevent graft-versus-host disease or rejection in transplanted organs, such as bone marrow and pancreas. The design and development of these molecules, as well as a clinical development plan, will be discussed.

Original languageEnglish (US)
Pages (from-to)437-446
Number of pages10
JournalJournal of Biological Response Modifiers
Volume4
Issue number5
StatePublished - Oct 1985

Keywords

  • Immunotoxin

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research

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