Antidepressant actions of ketamine: From molecular mechanisms to clinical practice

Lisa M Monteggia, Carlos Zarate

Research output: Contribution to journalReview article

88 Scopus citations


In the past decade the emergence of glutamate N-methyl- d-aspartate (NMDA) receptor blockers such as ketamine as fast-acting antidepressants fostered a major conceptual advance by demonstrating the possibility of a rapid antidepressant response. This discovery brings unique mechanistic insight into antidepressant action, as there is a substantial amount of basic knowledge on glutamatergic neurotransmission and how blockade of NMDA receptors may elicit plasticity. The combination of this basic knowledge base and the growing clinical findings will facilitate the development of novel fast acting antidepressants.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalCurrent Opinion in Neurobiology
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Neuroscience(all)

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