Antiepiligrin cicatricial pemphigoid of the larynx successfully treated with a combination of tetracycline and niacinamide

Kikuo Sakamoto, Kazunori Mori, Takashi Hashimoto, Kim B. Yancey, Tadashi Nakashima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A case of antiepiligrin cicatricial pemphigoid that primarily involved the larynx and required a tracheostomy was studied. The diagnosis was based on the direct immunofluorescence findings of a biopsy specimen from the glottis, immunofluorescence using normal and 1M sodium chloride-split normal human skin as substrates, and immunoprecipitation. A dramatic clinical improvement was observed after the combined administration of tetracycline hydrochloride and niacinamide. The tracheal stoma could be shut after the narrow segment was cut by means of carbon dioxide laser therapy. The patient showed no respiratory difficulty during the 2-year follow-up period. The combined therapy of tetracycline and niacinamide is thus considered to be an effective treatment for various types of cicatricial pemphigoid.

Original languageEnglish (US)
Pages (from-to)1420-1423
Number of pages4
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume128
Issue number12
StatePublished - Dec 1 2002

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Benign Mucous Membrane Pemphigoid
Niacinamide
Larynx
Tetracycline
Glottis
Direct Fluorescent Antibody Technique
Gas Lasers
Tracheostomy
Laser Therapy
Immunoprecipitation
Sodium Chloride
Fluorescent Antibody Technique
Biopsy
Skin
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Antiepiligrin cicatricial pemphigoid of the larynx successfully treated with a combination of tetracycline and niacinamide. / Sakamoto, Kikuo; Mori, Kazunori; Hashimoto, Takashi; Yancey, Kim B.; Nakashima, Tadashi.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 128, No. 12, 01.12.2002, p. 1420-1423.

Research output: Contribution to journalArticle

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