TY - JOUR
T1 - Antiepiligrin cicatricial pemphigoid
T2 - The first case report from Japan
AU - Hashimoto, Takashi
AU - Murakami, Hector
AU - Senboshi, Yasuko
AU - Kanzaki, Hiroko
AU - Arata, Jiro
AU - Yancey, Kim B.
AU - Nishikawa, Takeji
N1 - Funding Information:
From the Deparmaent of Dermatology, Keio University School of Medicine, a the Department of Dermatology, Okayama University Medical School, b and the Dermatology Branch, National Institutes of Health. c Supported in part by Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (04454289), a grant from the Ministry of Health and Welfare of Japan. Reprint requests: Takashi Hashimoto, MD, Department of Dermatol-ogy, Keio University School of Medicine, 35 Shinanomachi, Shin-juku, Tokyo 160, Japan. Copyright © 1996 by the American Academy of Dermatology, Inc. 0190-9622/96 $5.00 + 0 16/4/70832
PY - 1996/5
Y1 - 1996/5
N2 - We describe a Japanese man with antiepiligrin cicatricial pemphigoid and typical clinical features, including ocular involvement. Direct immunofluorescence showed IgG deposition at the basement membrane zone. Indirect immunofluorescence of IM sodium chloride-split skin showed circulating antibasement membrane zone antibodies of IgG class reactive with the dermal side of the split. Immunoblotting of human epidermal and dermal extracts, as well as a bacterial fusion protein of BP180 NC16a domain, showed no specific reactivity. In contrast, with immunoprecipitation of either culture medium or cell lysate from normal keratinocytes, the patient s serum clearly reacted with the protein epiligrin, a laminin isoform present in the lamina lucida of the human epidermal basement membrane zone. This is the first confirmed case of a Japanese patient with this disease entity.
AB - We describe a Japanese man with antiepiligrin cicatricial pemphigoid and typical clinical features, including ocular involvement. Direct immunofluorescence showed IgG deposition at the basement membrane zone. Indirect immunofluorescence of IM sodium chloride-split skin showed circulating antibasement membrane zone antibodies of IgG class reactive with the dermal side of the split. Immunoblotting of human epidermal and dermal extracts, as well as a bacterial fusion protein of BP180 NC16a domain, showed no specific reactivity. In contrast, with immunoprecipitation of either culture medium or cell lysate from normal keratinocytes, the patient s serum clearly reacted with the protein epiligrin, a laminin isoform present in the lamina lucida of the human epidermal basement membrane zone. This is the first confirmed case of a Japanese patient with this disease entity.
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U2 - 10.1016/S0190-9622(96)90086-9
DO - 10.1016/S0190-9622(96)90086-9
M3 - Article
C2 - 8621835
AN - SCOPUS:0029971771
SN - 0190-9622
VL - 34
SP - 940
EP - 942
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5 II
ER -