Antiepiligrin cicatricial pemphigoid: The first case report from Japan

Takashi Hashimoto, Hector Murakami, Yasuko Senboshi, Hiroko Kanzaki, Jiro Arata, Kim B. Yancey, Takeji Nishikawa

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We describe a Japanese man with antiepiligrin cicatricial pemphigoid and typical clinical features, including ocular involvement. Direct immunofluorescence showed IgG deposition at the basement membrane zone. Indirect immunofluorescence of IM sodium chloride-split skin showed circulating antibasement membrane zone antibodies of IgG class reactive with the dermal side of the split. Immunoblotting of human epidermal and dermal extracts, as well as a bacterial fusion protein of BP180 NC16a domain, showed no specific reactivity. In contrast, with immunoprecipitation of either culture medium or cell lysate from normal keratinocytes, the patient s serum clearly reacted with the protein epiligrin, a laminin isoform present in the lamina lucida of the human epidermal basement membrane zone. This is the first confirmed case of a Japanese patient with this disease entity.

Original languageEnglish (US)
Pages (from-to)940-942
Number of pages3
JournalJournal of the American Academy of Dermatology
Volume34
Issue number5 II
DOIs
StatePublished - May 1996

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Benign Mucous Membrane Pemphigoid
Japan
Basement Membrane
Skin
Immunoglobulin G
Direct Fluorescent Antibody Technique
Bacterial Proteins
Immunoglobulin Isotypes
Laminin
Indirect Fluorescent Antibody Technique
Keratinocytes
Immunoprecipitation
Immunoblotting
Sodium Chloride
Culture Media
Protein Isoforms
Membranes
Serum
Proteins

ASJC Scopus subject areas

  • Dermatology

Cite this

Antiepiligrin cicatricial pemphigoid : The first case report from Japan. / Hashimoto, Takashi; Murakami, Hector; Senboshi, Yasuko; Kanzaki, Hiroko; Arata, Jiro; Yancey, Kim B.; Nishikawa, Takeji.

In: Journal of the American Academy of Dermatology, Vol. 34, No. 5 II, 05.1996, p. 940-942.

Research output: Contribution to journalArticle

Hashimoto, T, Murakami, H, Senboshi, Y, Kanzaki, H, Arata, J, Yancey, KB & Nishikawa, T 1996, 'Antiepiligrin cicatricial pemphigoid: The first case report from Japan', Journal of the American Academy of Dermatology, vol. 34, no. 5 II, pp. 940-942. https://doi.org/10.1016/S0190-9622(96)90086-9
Hashimoto, Takashi ; Murakami, Hector ; Senboshi, Yasuko ; Kanzaki, Hiroko ; Arata, Jiro ; Yancey, Kim B. ; Nishikawa, Takeji. / Antiepiligrin cicatricial pemphigoid : The first case report from Japan. In: Journal of the American Academy of Dermatology. 1996 ; Vol. 34, No. 5 II. pp. 940-942.
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