Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain α,ω-bis-aminoalcohols

Gillian M. Nicholas, Ronghua Li, John B. MacMillan, Tadeusz F. Molinski

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The in vitro antifungal activity of a series of α,ω-bifunctionalized aminoalcohols against Candida glabrata was measured. The dimeric bi-functionalized lipids exhibited activity about ∼10-fold higher higher than D-sphingosine, which is a larger factor than expected from the simple additive effects of vicinal aminoalcohols groups.

Original languageEnglish (US)
Pages (from-to)2159-2162
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number16
DOIs
StatePublished - Aug 19 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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