Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

Yuanzeng Min; Kyle C. Roche; Shaomin Tian; Michael J. Eblan; Karen P. McKinnon; Joseph M. Caster; Shengjie Chai; Laura E. Herring; Longzhen Zhang; Tian Zhang; Joseph M. Desimone; Joel E. Tepper; Benjamin G. Vincent; Jonathan S. Serody; Andrew Z. Wang

doi:10.1038/nnano.2017.113

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

Yuanzeng Min, Kyle C. Roche, Shaomin Tian, Michael J. Eblan, Karen P. McKinnon, Joseph M. Caster, Shengjie Chai, Laura E. Herring, Longzhen Zhang, Tian Zhang, Joseph M. Desimone, Joel E. Tepper, Benjamin G. Vincent, Jonathan S. Serody, Andrew Z. Wang

Research output: Contribution to journal › Article › peer-review

523 Scopus citations

Abstract

Immunotherapy holds tremendous promise for improving cancer treatment. To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the abscopal effect'. Unfortunately, response rates for this strategy remain low. Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC-NP formulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is dependent on the NP surface properties. We showed that AC-NPs deliver tumour-specific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of αPD-1 (anti-programmed cell death 1) treatment using the B16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC-NPs. Mechanistic studies revealed that AC-NPs induced an expansion of CD8 + cytotoxic T cells and increased both CD4 + T/T reg and CD8 + T/T reg ratios (T reg, regulatory T cells). Our work presents a novel strategy to improve cancer immunotherapy with nanotechnology.

Original language	English (US)
Pages (from-to)	877-882
Number of pages	6
Journal	Nature Nanotechnology
Volume	12
Issue number	9
DOIs	https://doi.org/10.1038/nnano.2017.113
State	Published - Sep 1 2017
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Atomic and Molecular Physics, and Optics
Biomedical Engineering
General Materials Science
Condensed Matter Physics
Electrical and Electronic Engineering

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Min, Y., Roche, K. C., Tian, S., Eblan, M. J., McKinnon, K. P., Caster, J. M., Chai, S., Herring, L. E., Zhang, L., Zhang, T., Desimone, J. M., Tepper, J. E., Vincent, B. G., Serody, J. S., & Wang, A. Z. (2017). Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy. Nature Nanotechnology, 12(9), 877-882. https://doi.org/10.1038/nnano.2017.113

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abstract = "Immunotherapy holds tremendous promise for improving cancer treatment. To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the abscopal effect'. Unfortunately, response rates for this strategy remain low. Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC-NP formulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is dependent on the NP surface properties. We showed that AC-NPs deliver tumour-specific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of αPD-1 (anti-programmed cell death 1) treatment using the B16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC-NPs. Mechanistic studies revealed that AC-NPs induced an expansion of CD8 + cytotoxic T cells and increased both CD4 + T/T reg and CD8 + T/T reg ratios (T reg, regulatory T cells). Our work presents a novel strategy to improve cancer immunotherapy with nanotechnology.",

author = "Yuanzeng Min and Roche, {Kyle C.} and Shaomin Tian and Eblan, {Michael J.} and McKinnon, {Karen P.} and Caster, {Joseph M.} and Shengjie Chai and Herring, {Laura E.} and Longzhen Zhang and Tian Zhang and Desimone, {Joseph M.} and Tepper, {Joel E.} and Vincent, {Benjamin G.} and Serody, {Jonathan S.} and Wang, {Andrew Z.}",

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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

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