Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

Yuanzeng Min, Kyle C. Roche, Shaomin Tian, Michael J. Eblan, Karen P. McKinnon, Joseph M. Caster, Shengjie Chai, Laura E. Herring, Longzhen Zhang, Tian Zhang, Joseph M. Desimone, Joel E. Tepper, Benjamin G. Vincent, Jonathan S. Serody, Andrew Z. Wang

Research output: Contribution to journalArticlepeer-review

385 Scopus citations

Abstract

Immunotherapy holds tremendous promise for improving cancer treatment. To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the abscopal effect'. Unfortunately, response rates for this strategy remain low. Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC-NP formulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is dependent on the NP surface properties. We showed that AC-NPs deliver tumour-specific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of αPD-1 (anti-programmed cell death 1) treatment using the B16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC-NPs. Mechanistic studies revealed that AC-NPs induced an expansion of CD8 + cytotoxic T cells and increased both CD4 + T/T reg and CD8 + T/T reg ratios (T reg, regulatory T cells). Our work presents a novel strategy to improve cancer immunotherapy with nanotechnology.

Original languageEnglish (US)
Pages (from-to)877-882
Number of pages6
JournalNature Nanotechnology
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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