Antimicrobial therapy in experimental pseudomonas infection

M. Z. Thomas, P. M. Southern

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Abstract

Young adult mice were infected with recent clinical isolates of Pseudomonas aeruginosa (P.a.). The LD50 in utreated mice was 6.7 X 107 organisms for one strain (MS2) and 2.5 X 107 organisms for the other (MZT624). Non infected injected controls all survived. Mortality in utreated controls was 73% (MS2) and 83% (MZT624). Treated animals received carbenicillin (CA), colistimethate (CO), gentamicin (GE) or polymyxin B (PB), either singly or in various combinations. MS2 infections were significantly ameliorated by CA or PB singly (53% and 40% mortality) and by several combinations (12.5% to 45% mortality). MZT624 infections were significantly altered by GE, GE plus PB, and by 2 3 drug regimens (29% to 43% mortality). In this model CA, GE, and PB were the most effective single anti P.a. agents; CA plus PB or GE, and GE plus PB were the most effective 2 drug combinations. No instances of in vivo synergism were observed.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalTexas reports on biology and medicine
Volume32
Issue number2
StatePublished - Dec 1 1974

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ASJC Scopus subject areas

  • Medicine(all)

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