Abstract
The fruit of Broussonetia papyrifera (L.) L'Herit. ex Vent. is a traditional Chinese medicine with Chinese name Chushizi. It has been commonly used as an important tonic for the treatment of age-related disorders. In this work, the antioxidant properties of the oil were investigated on nitric oxide production in lipopolysaccharide (LPS), activated RAW264.7 cells along with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion and hydroxyl radical scavenging assays. The chemical composition of the oil was analyzed by Gas chromatography-mass spectrometry (GC-MS). The oil mainly consists of 8, 11-octadecadienic acid (79.17%). It possessed DPPH/superoxide anion/hydroxyl free radical scavenging and NO production inhibition activities (IC50 58.00±0.37 μg/ml). The results indicated that Chushizi oil was a powerful antioxidant with versatile free radical-scavenging activity, which may have therapeutic potential in associated with various inflammatory diseases.
Original language | English (US) |
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Pages (from-to) | 6407-6412 |
Number of pages | 6 |
Journal | Journal of Medicinal Plant Research |
Volume | 5 |
Issue number | 28 |
DOIs | |
State | Published - Nov 30 2011 |
Externally published | Yes |
Keywords
- Anti-inflammatory
- Antioxidant
- Broussonetia papyrifera
- Chushizi
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Plant Science
- Complementary and alternative medicine