Antioxidative and anti-inflammatory properties of chushizi oil from Fructus Broussonetiae

Hongfang Zhao, Linzhang Huang, Luping Qin, Baokang Huan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The fruit of Broussonetia papyrifera (L.) L'Herit. ex Vent. is a traditional Chinese medicine with Chinese name Chushizi. It has been commonly used as an important tonic for the treatment of age-related disorders. In this work, the antioxidant properties of the oil were investigated on nitric oxide production in lipopolysaccharide (LPS), activated RAW264.7 cells along with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion and hydroxyl radical scavenging assays. The chemical composition of the oil was analyzed by Gas chromatography-mass spectrometry (GC-MS). The oil mainly consists of 8, 11-octadecadienic acid (79.17%). It possessed DPPH/superoxide anion/hydroxyl free radical scavenging and NO production inhibition activities (IC50 58.00±0.37 μg/ml). The results indicated that Chushizi oil was a powerful antioxidant with versatile free radical-scavenging activity, which may have therapeutic potential in associated with various inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)6407-6412
Number of pages6
JournalJournal of Medicinal Plant Research
Volume5
Issue number28
DOIs
StatePublished - Nov 30 2011
Externally publishedYes

Keywords

  • Anti-inflammatory
  • Antioxidant
  • Broussonetia papyrifera
  • Chushizi

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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