Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: Part i

Anna Caruso, Adele Chimento, Hussein El-Kashef, Jean Charles Lancelot, Antonella Panno, Vincenzo Pezzi, Carmela Saturnino, Maria Stefania Sinicropi, Rosa Sirianni, Sylvain Rault

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Several 9H-carbazole derivatives are used for various pharmacological applications. Many of these compounds demonstrated cytotoxic and anticancer activities. In this work, we have investigated the cytotoxic activity of some substituted carbazoles against cancer cell lines (MCF-7, and ISK). The derivative 2a showed the highest inhibitory activity against both cell lines.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume27
Issue number4
DOIs
StatePublished - Aug 2012

Keywords

  • Anticancer
  • Carbazoles
  • Ishikawa cell line
  • MCF-7 cell line

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Caruso, A., Chimento, A., El-Kashef, H., Lancelot, J. C., Panno, A., Pezzi, V., Saturnino, C., Sinicropi, M. S., Sirianni, R., & Rault, S. (2012). Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: Part i. Journal of Enzyme Inhibition and Medicinal Chemistry, 27(4), 609-613. https://doi.org/10.3109/14756366.2011.603132