Antiproton radiotherapy

Niels Bassler, Jan Alsner, Gerd Beyer, John J. DeMarco, Michael Doser, Dragan Hajdukovic, Oliver Hartley, Keisuke S. Iwamoto, Oliver Jäkel, Helge V. Knudsen, Sandra Kovacevic, Søren Pape Møller, Jens Overgaard, Jørgen B. Petersen, Timothy D. Solberg, Brita S. Sørensen, Sanja Vranjes, Bradly G. Wouters, Michael H. Holzscheiter

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Antiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton-proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with ∼20-30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the radiobiological properties using the antiproton beam available at CERN, Geneva. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with V79 WNRE Chinese hamster cells. The radiobiological experiments were repeated with protons and carbon ions at TRIUMF and GSI, respectively, for comparison. Several Monte Carlo particle transport codes were investigated and compared with our experimental data obtained at CERN. The code that matched our data best was used to generate a set of depth dose data at several energies, including secondary particle-energy spectra. This can be used as base data for a treatment planning software such as TRiP. Our findings from the CERN experiments indicate that the biological effect of antiprotons in the plateau region may be reduced by a factor of 4 for the same biological target dose in a spread-out Bragg-peak, when comparing with protons. The extension of TRiP to handle antiproton beams is currently in progress. This will enable us to perform planning studies, where the potential clinical consequences can be examined, and compared to those of other beam modalities such as protons, carbon ions, or IMRT photons.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalRadiotherapy and Oncology
Volume86
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Protons
Radiotherapy
Mesons
Carbon
Ions
Radiobiology
Linear Energy Transfer
Cricetulus
Photons
Alanine
Software

Keywords

  • Antiproton
  • Particle irradiation
  • RBE

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Urology

Cite this

Bassler, N., Alsner, J., Beyer, G., DeMarco, J. J., Doser, M., Hajdukovic, D., ... Holzscheiter, M. H. (2008). Antiproton radiotherapy. Radiotherapy and Oncology, 86(1), 14-19. https://doi.org/10.1016/j.radonc.2007.11.028

Antiproton radiotherapy. / Bassler, Niels; Alsner, Jan; Beyer, Gerd; DeMarco, John J.; Doser, Michael; Hajdukovic, Dragan; Hartley, Oliver; Iwamoto, Keisuke S.; Jäkel, Oliver; Knudsen, Helge V.; Kovacevic, Sandra; Møller, Søren Pape; Overgaard, Jens; Petersen, Jørgen B.; Solberg, Timothy D.; Sørensen, Brita S.; Vranjes, Sanja; Wouters, Bradly G.; Holzscheiter, Michael H.

In: Radiotherapy and Oncology, Vol. 86, No. 1, 01.2008, p. 14-19.

Research output: Contribution to journalArticle

Bassler, N, Alsner, J, Beyer, G, DeMarco, JJ, Doser, M, Hajdukovic, D, Hartley, O, Iwamoto, KS, Jäkel, O, Knudsen, HV, Kovacevic, S, Møller, SP, Overgaard, J, Petersen, JB, Solberg, TD, Sørensen, BS, Vranjes, S, Wouters, BG & Holzscheiter, MH 2008, 'Antiproton radiotherapy', Radiotherapy and Oncology, vol. 86, no. 1, pp. 14-19. https://doi.org/10.1016/j.radonc.2007.11.028
Bassler N, Alsner J, Beyer G, DeMarco JJ, Doser M, Hajdukovic D et al. Antiproton radiotherapy. Radiotherapy and Oncology. 2008 Jan;86(1):14-19. https://doi.org/10.1016/j.radonc.2007.11.028
Bassler, Niels ; Alsner, Jan ; Beyer, Gerd ; DeMarco, John J. ; Doser, Michael ; Hajdukovic, Dragan ; Hartley, Oliver ; Iwamoto, Keisuke S. ; Jäkel, Oliver ; Knudsen, Helge V. ; Kovacevic, Sandra ; Møller, Søren Pape ; Overgaard, Jens ; Petersen, Jørgen B. ; Solberg, Timothy D. ; Sørensen, Brita S. ; Vranjes, Sanja ; Wouters, Bradly G. ; Holzscheiter, Michael H. / Antiproton radiotherapy. In: Radiotherapy and Oncology. 2008 ; Vol. 86, No. 1. pp. 14-19.
@article{e4469d4a93f04278831776c7c8c5697c,
title = "Antiproton radiotherapy",
abstract = "Antiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton-proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with ∼20-30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the radiobiological properties using the antiproton beam available at CERN, Geneva. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with V79 WNRE Chinese hamster cells. The radiobiological experiments were repeated with protons and carbon ions at TRIUMF and GSI, respectively, for comparison. Several Monte Carlo particle transport codes were investigated and compared with our experimental data obtained at CERN. The code that matched our data best was used to generate a set of depth dose data at several energies, including secondary particle-energy spectra. This can be used as base data for a treatment planning software such as TRiP. Our findings from the CERN experiments indicate that the biological effect of antiprotons in the plateau region may be reduced by a factor of 4 for the same biological target dose in a spread-out Bragg-peak, when comparing with protons. The extension of TRiP to handle antiproton beams is currently in progress. This will enable us to perform planning studies, where the potential clinical consequences can be examined, and compared to those of other beam modalities such as protons, carbon ions, or IMRT photons.",
keywords = "Antiproton, Particle irradiation, RBE",
author = "Niels Bassler and Jan Alsner and Gerd Beyer and DeMarco, {John J.} and Michael Doser and Dragan Hajdukovic and Oliver Hartley and Iwamoto, {Keisuke S.} and Oliver J{\"a}kel and Knudsen, {Helge V.} and Sandra Kovacevic and M{\o}ller, {S{\o}ren Pape} and Jens Overgaard and Petersen, {J{\o}rgen B.} and Solberg, {Timothy D.} and S{\o}rensen, {Brita S.} and Sanja Vranjes and Wouters, {Bradly G.} and Holzscheiter, {Michael H.}",
year = "2008",
month = "1",
doi = "10.1016/j.radonc.2007.11.028",
language = "English (US)",
volume = "86",
pages = "14--19",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Antiproton radiotherapy

AU - Bassler, Niels

AU - Alsner, Jan

AU - Beyer, Gerd

AU - DeMarco, John J.

AU - Doser, Michael

AU - Hajdukovic, Dragan

AU - Hartley, Oliver

AU - Iwamoto, Keisuke S.

AU - Jäkel, Oliver

AU - Knudsen, Helge V.

AU - Kovacevic, Sandra

AU - Møller, Søren Pape

AU - Overgaard, Jens

AU - Petersen, Jørgen B.

AU - Solberg, Timothy D.

AU - Sørensen, Brita S.

AU - Vranjes, Sanja

AU - Wouters, Bradly G.

AU - Holzscheiter, Michael H.

PY - 2008/1

Y1 - 2008/1

N2 - Antiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton-proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with ∼20-30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the radiobiological properties using the antiproton beam available at CERN, Geneva. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with V79 WNRE Chinese hamster cells. The radiobiological experiments were repeated with protons and carbon ions at TRIUMF and GSI, respectively, for comparison. Several Monte Carlo particle transport codes were investigated and compared with our experimental data obtained at CERN. The code that matched our data best was used to generate a set of depth dose data at several energies, including secondary particle-energy spectra. This can be used as base data for a treatment planning software such as TRiP. Our findings from the CERN experiments indicate that the biological effect of antiprotons in the plateau region may be reduced by a factor of 4 for the same biological target dose in a spread-out Bragg-peak, when comparing with protons. The extension of TRiP to handle antiproton beams is currently in progress. This will enable us to perform planning studies, where the potential clinical consequences can be examined, and compared to those of other beam modalities such as protons, carbon ions, or IMRT photons.

AB - Antiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton-proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with ∼20-30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the radiobiological properties using the antiproton beam available at CERN, Geneva. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with V79 WNRE Chinese hamster cells. The radiobiological experiments were repeated with protons and carbon ions at TRIUMF and GSI, respectively, for comparison. Several Monte Carlo particle transport codes were investigated and compared with our experimental data obtained at CERN. The code that matched our data best was used to generate a set of depth dose data at several energies, including secondary particle-energy spectra. This can be used as base data for a treatment planning software such as TRiP. Our findings from the CERN experiments indicate that the biological effect of antiprotons in the plateau region may be reduced by a factor of 4 for the same biological target dose in a spread-out Bragg-peak, when comparing with protons. The extension of TRiP to handle antiproton beams is currently in progress. This will enable us to perform planning studies, where the potential clinical consequences can be examined, and compared to those of other beam modalities such as protons, carbon ions, or IMRT photons.

KW - Antiproton

KW - Particle irradiation

KW - RBE

UR - http://www.scopus.com/inward/record.url?scp=38349091677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349091677&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2007.11.028

DO - 10.1016/j.radonc.2007.11.028

M3 - Article

VL - 86

SP - 14

EP - 19

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 1

ER -