Antisense antibacterial compounds

Reed Pifer, David E. Greenberg

Research output: Contribution to journalReview article

Abstract

Extensive antibiotic use combined with poor historical drug stewardship practices have created a medical crisis in which once treatable bacterial infections are now increasingly unmanageable. To combat this, new antibiotics will need to be developed and safeguarded. An emerging class of antibiotics based upon nuclease-stable antisense technologies has proven valuable in preclinical testing against a variety of bacterial pathogens. This review describes the current state of development of antisense-based antibiotics, the mechanisms thus far employed by these compounds, and possible future avenues of research.

Original languageEnglish (US)
Pages (from-to)89-106
Number of pages18
JournalTranslational Research
Volume223
DOIs
StatePublished - Sep 2020

Keywords

  • Antibiotic resistance
  • Antibiotics
  • Antisense
  • PPMOs
  • Peptide-conjugated phosphorodiamidate morpholino oligomers

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

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